ChemSpider 2D Image | (-)-Gambogic acid | C38H44O8

(-)-Gambogic acid

  • Molecular FormulaC38H44O8
  • Average mass628.751 Da
  • Monoisotopic mass628.303589 Da
  • ChemSpider ID8027898

  • Double-bond stereo - Double-bond stereo

    defined stereocentres - 5 of 5 defined stereocentres

More details:

Featured data source
The Merck Index Online

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(-)-Gambogic acid
(2Z)-4-[(1S,2S,8R,17S,19R)-12-Hydroxy-8,21,21-trimethyl-5-(3-methyl-2-buten-1-yl)-8-(4-methyl-3-penten-1-yl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.02,15.02,19.04,13.06,11]docosa-4(13),5,9,
 11,15-pentaen-19-yl]-2-methyl-2-butenoic acid [ACD/IUPAC Name]
(2Z)-4-[(1S,2S,8R,17S,19R)-12-Hydroxy-8,21,21-trimethyl-5-(3-methyl-2-buten-1-yl)-8-(4-methyl-3-penten-1-yl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.02,15.02,19.04,13.06,11]docosa-4(13),5,9,
 11,15-pentaen-19-yl]-2-methyl-2-butensäure [German] [ACD/IUPAC Name]
1,5-Methano-1H,3H,11H-furo(3,4-g)pyrano(3,2-b)xanthene-1-crotonic acid
2-Butenoic acid, 2-methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-buten-1-yl)-11-(4-methyl-3-penten-1-yl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyra no[3,2-b]xanthen-1-yl]-, (2Z)- [ACD/Index Name]
8N585K83U2
Acide (2Z)-4-[(1S,2S,8R,17S,19R)-12-hydroxy-8,21,21-triméthyl-5-(3-méthyl-2-butén-1-yl)-8-(4-méthyl-3-pentén-1-yl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.02,15.02,19.04,13.06,11]docosa-4(13 
),5,9,11,15-pentaén-19-yl]-2-méthyl-2-buténoïque [French] [ACD/IUPAC Name]
B"-Guttiferrin
Cambogic acid
Gambogic acid [Wiki]
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Apoptosis MedChem Express HY-N0087
      Apoptosis; MedChem Express HY-N0087
      Bcl-2 Family MedChem Express HY-N0087
      Gambogic Acid activates caspases with EC50 of 0.78-1.64 ?M and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 ?M, respectively.; IC50 Value: 1.21 uM (Bcl-2); 1.47 uM (Bcl-xl); Target: Bcl-2 Family; in vitro: Gambogic acid is a xanthonoid that is derived from the brownish or orange resin from Garcinia hanburyi. MedChem Express HY-N0087

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point: 808.9±65.0 °C at 760 mmHg
Vapour Pressure: 0.0±3.0 mmHg at 25°C
Enthalpy of Vaporization: 123.3±3.0 kJ/mol
Flash Point: 251.4±27.8 °C
Index of Refraction: 1.627
Molar Refractivity: 172.0±0.4 cm3
#H bond acceptors: 8
#H bond donors: 2
#Freely Rotating Bonds: 8
#Rule of 5 Violations: 2
ACD/LogP: 10.30
ACD/LogD (pH 5.5): 7.60
ACD/BCF (pH 5.5): 203843.16
ACD/KOC (pH 5.5): 114729.91
ACD/LogD (pH 7.4): 5.14
ACD/BCF (pH 7.4): 709.09
ACD/KOC (pH 7.4): 399.10
Polar Surface Area: 119 Å2
Polarizability: 68.2±0.5 10-24cm3
Surface Tension: 59.0±5.0 dyne/cm
Molar Volume: 485.0±5.0 cm3

Click to predict properties on the Chemicalize site


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