(1'R,2S,4'S,5S,6R,8'R,10'E,12'S,13'S,14'E,16'E,20'S,24'S)-6-[(2S)-2-Butanyl]-12',24'-dihydroxy-5,11',13',22'-tetramethyl-5,6-dihydro-2'H,21'H-spiro[pyran-2,6'-[3,7,19]trioxatetracyclo[15.6.1.1^4,8.0^20,24]pentacosa[10,14,16,22]tetraene]-2',21'-dione

ChemSpider ID: 10128283
Molecular Formula: C₃₄H₄₆O₈
Average mass: 582.723999 Da
Monoisotopic mass: 582.31897 Da
Systematic name

(1'R,2S,4'S,5S,6R,8'R,10'E,12'S,13'S,14'E,16'E,20'S,24'S)-6-[(2S)-2-Butanyl]-12',24'-dihydroxy-5,11',13',22'-tetramethyl-5,6-dihydro-2'H,21'H-spiro[pyran-2,6'-[3,7,19]trioxatetracyclo[15.6.1.1^4,8.0^20,24]pentacosa[10,14,16,22]tetraene]-2',21'-dione
SMILES and InChIs

SMILES:

O=C2O[C@@H]5C[C@@]/1(O[C@H](C(C)CC)[C@H](\C=C\1)C)O[C@H](C/C=C(\C)[C@@H](O)[C@H](/C=C/C=C3/[C@@]4(O)[C@H]2/C=C(\C(=O)[C@H]4OC3)C)C)C5 Copied

Std. InChI:

InChI=1S/C34H46O8/c1-7-19(2)30-22(5)13-14-33(42-30)17-26-16-25(41-33)12-11-21(4)28(35)20(3)9-8-10-24-18-39-31-29(36)23(6)15-27(32(37)40-26)34(24,31)38/h8-11,13-15,19-20,22,25-28,30-31,35,38H,7,12,16-18H2,1-6H3/b9-8+,21-11+,24-10+/t19?,20-,22-,25+,26-,27-,28-,30+,31+,33+,34+/m0/s1 Copied

Std. InChIKey:

ZSPNNRIPLTXTIF-ZJHNFQRCSA-N Copied
Cite this record
CSID:10128283, http://www.chemspider.com/Chemical-Structure.10128283.html (accessed 03:29, May 21, 2013) Copied

Names and Identifiers

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Predicted data is generated using the ACD/Labs’ ACD/PhysChem Suite, for more information see their website.

ACD/LogP:	5.211	# of Rule of 5 Violations:	2
ACD/LogD (pH 5.5):	5.21	ACD/LogD (pH 7.4):	5.21
ACD/BCF (pH 5.5):	5376.06	ACD/BCF (pH 7.4):	5375.90
ACD/KOC (pH 5.5):	16287.66	ACD/KOC (pH 7.4):	16287.16
#H bond acceptors:	8	#H bond donors:	2
#Freely Rotating Bonds:	4	Polar Surface Area:	111.52 Å²
Index of Refraction:	1.582	Molar Refractivity:	158.222 cm³
Molar Volume:	474.161 cm³	Polarizability:	62.724 10^-24cm³
Surface Tension:	51.7150001525879 dyne/cm	Density:	1.229 g/cm³
Flash Point:	245.881 °C	Enthalpy of Vaporization:	129.343 kJ/mol
Boiling Point:	779.8 °C at 760 mmHg	Vapour Pressure:	0 mmHg at 25°C

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Publication or Magazine Article	Web-based Article (blog or commentary)
Available Chemicals Databases	Biological Properties
Chemical Reactions	Chemical Safety Data
Drugs or Compounds in Development	Imaging Agents
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Pharmacological Links

SimBioSys LASSO

Category	Target	PDB Code	LASSO Score
Nuclear Hormone Receptors	GR, glucocorticoid receptor	1m2z	0.10
Metalloenzymes	ACE, angiotensin-converting enzyme	1o86	0.03
Nuclear Hormone Receptors	PPARg, peroxisome proliferator activated receptor	1fm9	0.03
Kinases	PDGFrb, platelet derived growth factor receptor kinase	N/A	0.02
Kinases	SRC, tyrosine kinase SRC	2src	0.01
Other Enzymes	HMGR, hydroxymethylglutaryl-CoA reductase	1hw8	0.01
Other Enzymes	HIVPR, HIV protease	1hpx	0.01
Serine Proteases	Thrombin	1ba8	0.01
Kinases	HSP90, human heat shock protein 90	1uy6	0.01
Nuclear Hormone Receptors	MR, mineralocorticoid receptor	2aa2	0.01
Nuclear Hormone Receptors	RXRa, retinoic X receptor R	1mvc	0.01
Other Enzymes	PARP, poly(ADP-ribose) polymerase	1efy	0.01
Other Enzymes	PNP, purine nucleoside phosphorylase	1b8o	0.00
Other Enzymes	AmpC, AmpC beta-lactamase	1xgj	0.00
Nuclear Hormone Receptors	ER, estrogen receptor; agonist	1l2i	0.00
Folate Enzymes	DHFR, dihydrofolate reductase	3dfr	0.00
Nuclear Hormone Receptors	PR, progesterone receptor	1sr7	0.00
Other Enzymes	NA, neuraminidase	1a4g	0.00
Kinases	VEGFr2, vascular endothelial growth factor receptor	1vr2	0.00
Other Enzymes	GPB, glycogen phosphorylase	1a8i	0.00
Kinases	FGFr1, fibroblast growth factor receptor kinase	1agw	0.00
Other Enzymes	SAHH, S-adenosyl-homocysteine hydrolase	1a7a	0.00
Other Enzymes	COX-2, cyclooxygenase-2	1cx2	0.00
Kinases	CDK2, cyclindependent kinase 2	1ckp	0.00
Kinases	TK, thymidine kinase	1kim	0.00
Nuclear Hormone Receptors	AR, androgen receptor	1xq2	0.00
Other Enzymes	AChE, acetylcholinesterase	1eve	0.00
Kinases	P38 MAP, P38 mitogen activated protein	1kv2	0.00
Folate Enzymes	GART, glycinamide ribonucleotide transformylase	1c2t	0.00
Serine Proteases	FXa, factor Xa	1f0r	0.00
Metalloenzymes	ADA, adenosine deaminase	1stw	0.00
Metalloenzymes	COMT, catechol O-methyltransferase	1h1d	0.00
Kinases	EGFr, epidermal growth factor receptor	1m17	0.00
Other Enzymes	HIVRT, HIV reverse transcriptase	1rt1	0.00

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(1'R,2S,4'S,5S,6R,8'R,10'E,12'S,13'S,14'E,16'E,20'S,24'S)-6-[(2S)-2-Butanyl]-12',24'-dihydroxy-5,11',13',22'-tetramethyl-5,6-dihydro-2'H,21'H-spiro[pyran-2,6'-[3,7,19]trioxatetracyclo[15.6.1.1^4,8.0^20,24]pentacosa[10,14,16,22]tetraene]-2',21'-dione

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SimBioSys LASSO

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(1'R,2S,4'S,5S,6R,8'R,10'E,12'S,13'S,14'E,16'E,20'S,24'S)-6-[(2S)-2-Butanyl]-12',24'-dihydroxy-5,11',13',22'-tetramethyl-5,6-dihydro-2'H,21'H-spiro[pyran-2,6'-[3,7,19]trioxatetracyclo[15.6.1.14,8.0 20,24]pentacosa[10,14,16,22]tetraene]-2',21'-dione

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(1'R,2S,4'S,5S,6R,8'R,10'E,12'S,13'S,14'E,16'E,20'S,24'S)-6-[(2S)-2-Butanyl]-12',24'-dihydroxy-5,11',13',22'-tetramethyl-5,6-dihydro-2'H,21'H-spiro[pyran-2,6'-[3,7,19]trioxatetracyclo[15.6.1.1^4,8.0^20,24]pentacosa[10,14,16,22]tetraene]-2',21'-dione