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2BSS7XL60S

Molecular FormulaC₁₇H₂₁Cl₂N₃O₃
Average mass386.273 Da
Monoisotopic mass385.096008 Da
ChemSpider ID102928

More details:

Names and Synonyms
Database ID(s)

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

123040-16-4 [RN]

123040-69-7 [RN]

141922-90-9 [RN]

2BSS7XL60S

2H-1,4-Benzoxazine-8-carboxamide, N-1-azabicyclo[2.2.2]oct-3-yl-6-chloro-3,4-dihydro-4-methyl-3-oxo-, hydrochloride (1:1) [ACD/Index Name]

Azasetron (hydrochloride)

Azasetron HCl

Azasetron hydrochloride

N-(1-Azabicyclo[2.2.2]oct-3-yl)-6-chlor-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-8-carboxamidhydrochlorid (1:1) [German] [ACD/IUPAC Name]

N-(1-Azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide hydrochloride (1:1) [ACD/IUPAC Name]

More...

N-(1-Azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-méthyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide, chlorhydrate (1:1) [French] [ACD/IUPAC Name]

UNII:2BSS7XL60S

(-)-6-Chloro-4-methyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxylic acid (1-aza-bicyclo[2.2.2]oct-3-yl)-amide hydrochloride

(-)-Azasetron hydrochloride

(+)-6-Chloro-4-methyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxylic acid (1-aza-bicyclo[2.2.2]oct-3-yl)-amide hydrochloride

(+)-Azasetron hydrochloride

[123040-16-4] [RN]

1216505-58-6 [RN]

123040-93-7 [RN]

123040-94-8 [RN]

123040-96-0 [RN]

1329611-23-5 [RN]

1329834-62-9 [RN]

186787-32-6 [RN]

2H-1,4-Benzoxazine-8-carboxamide, 3,4-dihydro-N-1-azabicyclo(2.2.2)oct-3-yl-6-chloro-4-methyl-3-oxo-, monohydrochloride

2H-1,4-Benzoxazine-8-carboxamide, N-1-azabicyclo(2.2.2)oct-3-yl-6-chloro-3,4-dihydro-4-methyl-3-oxo-, monohydrochloride

2H-1,4-Benzoxazine-8-carboxamide, N-1-azabicyclo[2.2.2]oct-3-yl-6-chloro-3,4-dihydro-4-methyl-3-oxo-, monohydrochloride, (-)-

2H-1,4-Benzoxazine-8-carboxamide, N-1-azabicyclo[2.2.2]oct-3-yl-6-chloro-3,4-dihydro-4-methyl-3-oxo-, monohydrochloride, (+)-

2H-1,4-Benzoxazine-8-carboxamide,N-1-azabicyclo[2.2.2]oct-3-yl-6-chloro-3,4-dihydro-4-methyl-3-oxo-,monohydrochloride, (-)-

2H-1,4-Benzoxazine-8-carboxamide,N-1-azabicyclo[2.2.2]oct-3-yl-6-chloro-3,4-dihydro-4-methyl-3-oxo-,monohydrochloride, (+)-

33019-85-1 [RN]

477243-03-1 [RN]

6-Chloro-4-methyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxylic acid (1-aza-bicyclo[2.2.2]oct-3-yl)-amide hydrochloride

6-chloro-4-methyl-3-oxo-N-(quinuclidin-3-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxamide hydrochloride

Azasetron [INN] [Wiki]

Azasetron hydrochloride (JAN) [JAN]

Azasetron Hydrochloride?

azasetron-13c,d3 hydrochloride

Azasetron-d3 Hydrochloride

AzasetronHCl

AZASETRONHYDROCHLORIDE

D-erythro-Sphingosine (Brain, Porcine)

DM3001200

HYDROGEN AZASETRON CHLORIDE

Jsp001546

MFCD00209913 [MDL number]

N-(1-Azabicyclo[2,2,2]oct-3-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide hydrochloride

N-(1-Azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide hydrochloride

N-(1-azabicyclo[2.2.2]octan-3-yl)-6-chloranyl-4-methyl-3-oxidanylidene-1,4-benzoxazine-8-carboxamide hydrochloride

N-(1-azabicyclo[2.2.2]octan-3-yl)-6-chloro-4-methyl-3-oxo-1,4-benzoxazine-8-carboxamide and hydron and chloride

N-(1-azabicyclo[2.2.2]octan-3-yl)-6-chloro-4-methyl-3-oxo-1,4-benzoxazine-8-carboxamide hydrochloride

N-(1-azabicyclo[2.2.2]octan-3-yl)-6-chloro-4-methyl-3-oxo-1,4-benzoxazine-8-carboxamide;hydrochloride

N-(1-Azabicyclo[2.2.2]octan-8-yl)-6-chloro-4-methyl-3-oxo-1,4-benzoxazine-8-carboxamide hydrochloride

N-[(3S)-1-azoniabicyclo[2.2.2]octan-3-yl]-6-chloro-4-methyl-3-oxo-1,4-benzoxazine-8-carboxamide

N-{1-azabicyclo[2.2.2]octan-3-yl}-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide hydrochloride

N-1-azabicyclo[2.2.2]oct-3-yl-6-chloro-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxazine-8-carboxamide

N-1-Azabicyclo[2.2.2]-oct-3-yl-6-chloro-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxazine-8-carboxamide hydrochloride

N-1-Azabicyclo[2.2.2]oct-3-yl-6-chloro-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxazine-8-carboxamide monohydrochloride

Nazasetron hydrochloride

Serotone [Trade name]

Serotone (TN)

Y 25130 hydrochloride

Y25130

Y25130 hydrochloride

Y-25130 hydrochloride

Y-25130 hydrochloride;Y25130 hydrochloride;Y 25130 hydrochloride

Less...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

Y 25130 [DBID]

D01613 [DBID]

Y-25130 [DBID]

Experimental data
Predicted - ACD/Labs
Predicted - ChemAxon
Predicted - Mcule

Experimental Physico-chemical Properties

Experimental Solubility:

Miscellaneous

Target Organs:

5-HT Receptor antagonist TargetMol T1528

Bio Activity:

5-HT Receptor MedChem Express HY-B0068

5-HT Receptor TargetMol T1528

5-HT3 Receptors Tocris Bioscience 380

A selective and potent 5-HT3 antagonist (Ki = 2.9 nM). Tocris Bioscience 0380, 380

Azasetron HCl is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy. MedChem Express http://www.medchemexpress.com/granisetron-hydrochloride.html, HY-B0068

Azasetron HCl is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy. ;Target: 5-HT3 ReceptorAzasetron Hydrochloride is a 5-HT3 receptor antagonist which is used as an anti-emetic.Azasetron inhibited the specific binding of [3H]quipazine to 5-HT3 receptors at the synaptic membranes of the rat cerebral cortex with a Ki value of 2.9 nM. Azasetron showed low affinity for histamine H1 receptors (IC50 = 4.4 microM) but it could not reveal any affinities for the other receptors (5-HT1A, 5-HT2, dopamine D1, dopamine D2, alpha 1-adrenoceptor, alpha 2-adrenoceptor, muscarine and benzodiazepine) even at a 10 microM concentration [1]. Azasetron (0.1-1.0 mg/kg) dose-dependently prolonged the latency to the first vomiting and decreased the number of vomitings induced by cisplatin in dogs. Azasetron is an orally active antiemetic compound against cisplatin and doxorubicin/cyclophosphamide-induced emeses; an MedChem Express HY-B0068

GPCR/G protein MedChem Express HY-B0068

GPCR/G protein; Neuronal Signaling; MedChem Express HY-B0068

Ion Channels Tocris Bioscience 380

Ligand-gated Ion Channels Tocris Bioscience 380

Neuroscience TargetMol T1528

Potent, selective 5-HT3 antagonist Tocris Bioscience 0380, 380

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Density:
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction:
Molar Refractivity:
#H bond acceptors:
#H bond donors:
#Freely Rotating Bonds:
#Rule of 5 Violations:

ACD/LogP:
ACD/LogD (pH 5.5):
ACD/BCF (pH 5.5):
ACD/KOC (pH 5.5):
ACD/LogD (pH 7.4):
ACD/BCF (pH 7.4):
ACD/KOC (pH 7.4):
Polar Surface Area:
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Surface Tension:
Molar Volume:

Click to predict properties on the Chemicalize site

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2BSS7XL60S

More details:

Experimental Solubility:

Target Organs:

Bio Activity:

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