ChemSpider 2D Image | Gleevec | C30H35N7O4S

Gleevec

  • Molecular FormulaC30H35N7O4S
  • Average mass589.708 Da
  • Monoisotopic mass589.247131 Da
  • ChemSpider ID110189

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

Gleevec
152459-95-5 [RN]
220127-57-1 [RN]
4-[(4-Methyl-1-piperazinyl)methyl]-N-(4-methyl-3-{[4-(3-pyridinyl)-2-pyrimidinyl]amino}phenyl)benzamide methanesulfonate
4-[(4-Methyl-1-piperazinyl)methyl]-N-(4-methyl-3-{[4-(3-pyridinyl)-2-pyrimidinyl]amino}phenyl)benzamide methanesulfonate (1:1) [ACD/IUPAC Name]
4-[(4-Methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide methanesulfonate
4-[(4-Methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide methanesulfonate (1:1)
8A1O1M485B
Acide méthanesulfonique - 4-[(4-méthyl-1-pipérazinyl)méthyl]-N-(4-méthyl-3-{[4-(3-pyridinyl)-2-pyrimidinyl]amino}phényl)benzamide (1:1) [French] [ACD/IUPAC Name]
acide méthanesulfonique - 4-[(4-méthylpipérazin-1-yl)méthyl]-N-{4-méthyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phényl}benzamide (1:1) [French]
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CCRIS 4693 [DBID]
CGP 57148 [DBID]
CGP-57148 [DBID]
D01441 [DBID]
HSDB 7142 [DBID]
LS-27113 [DBID]
NSC716051 [DBID]
STI 571 [DBID]
STI-571 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      Bcr-Abl inhibitor;c-kit inhibitor; PDGFR inhibitor TargetMol T1621

    • Chemical Class:

      A methanesulfonate (mesylate) salt that is the monomesylate salt of imatinib. Used for treatment of chronic myelogenous leukemia and gastrointestinal stromal tumours. ChEBI CHEBI:31690

    • Bio Activity:

      Abl Kinase Tocris Bioscience 5906
      c-Kit MedChem Express HY-50946
      c-Kit PDGFR MedChem Express HY-50946
      Enzymes Tocris Bioscience 5906
      Imatinib(STI571) is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 ?M, 0.1 ?M and 0.1 ?M, respectively. MedChem Express HY-50946
      Kinases Tocris Bioscience 5906
      Potent and selective v-Abl tyrosine kinase inhibitor (IC50 = 38 nM). Also inhibits PDGFR and c-kit. Exhibits selectivity for v-Abl over a panel of other tyrosine and serine/threonine protein kinases. Selectively inhibits PDGF-stimulated growth of v-abl-transformed PB-3 cells and v-sis-transformed BALB/c 3T3 cells in vitro. Exhibits antitumor effects in mice bearing AMuLV or BABL/c 3T3 v-sis cells. Tocris Bioscience 5906
      Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kit Tocris Bioscience 5906
      Protein Tyrosine Kinase/RTK MedChem Express HY-50946
      Protein Tyrosine Kinase/RTK; MedChem Express HY-50946
      Tyrosine Kinase/Adaptors TargetMol T1621
      v-Abl; c-Kit; PDGFR TargetMol T1621

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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