ChemSpider 2D Image | Olmesartan medoxomil | C29H30N6O6

Olmesartan medoxomil

  • Molecular FormulaC29H30N6O6
  • Average mass558.585 Da
  • Monoisotopic mass558.222656 Da
  • ChemSpider ID115748

More details:



Featured data source



Validated by Experts, Validated by Users, Non-Validated, Removed by Users

Olmesartan medoxomil [INN] [USAN]
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylate
(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxy-2-propanyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-imidazole-5-carboxylate [ACD/IUPAC Name]
(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylate
(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylate
(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl-4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-carboxylat
(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl-4-(2-hydroxy-2-propanyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-imidazol-5-carboxylat [German] [ACD/IUPAC Name]
144689-63-4 [RN]
1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester [ACD/Index Name]
1H-imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CS-866 [DBID]
CS 866 [DBID]
D01204 [DBID]
KBio2_002490 [DBID]
KBio2_005058 [DBID]
KBio2_007626 [DBID]
KBio3_002711 [DBID]
KBioGR_001040 [DBID]
KBioSS_002498 [DBID]
LS-181818 [DBID]
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  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Safety:

      IRRITANT Matrix Scientific 076046
    • Target Organs:

      RAAS inhibitor; ACE inhibitor TargetMol T1518
    • Drug Status:

      approved BIONET-Key Organics KS-1182
    • Compound Source:

      synthetic Microsource [01505205]
    • Bio Activity:

      7-TM Receptors Tocris Bioscience 4620
      Angiogenesis;Endocrinology/ Hormones TargetMol T1518
      Angiotensin Receptor MedChem Express HY-17005
      Angiotensin Receptors Tocris Bioscience 4620
      Antihypertensive agent Zerenex Molecular [ZBioX-0064]
      GPCR/G protein MedChem Express HY-17005
      GPCR/G protein; MedChem Express HY-17005
      Olmesartan medoxomil(Olmetec; Benicar; CS 866) is an angiotensin II receptor antagonist which is used as an anti-hypertensive.; IC50 value: ; Target: angiotensin II receptor MedChem Express HY-17005
      Olmesartan medoxomil(Olmetec; Benicar; CS 866) is an angiotensin II receptor antagonist which is used as an anti-hypertensive.;IC50 value: ;Target: angiotensin II receptor MedChem Express HY-17005
      Peptide Receptors Tocris Bioscience 4620
      Prodrug metabolised in vivo to Olmesartan (Cat. No. 4616), a selective non-peptide angiotensin II type I receptor (AT1) antagonist. Selectively inhibits angiotensin II binding to AT1 receptors in bovi ne adrenal cortical membranes (IC50 = 7.7 nM), with no effect on AT2 receptors. Tocris Bioscience 4620
      Prodrug metabolised in vivo to Olmesartan (Cat. No. 4616), a selective non-peptide angiotensin II type I receptor (AT1) antagonist. Selectively inhibits angiotensin II binding to AT1 receptors in bovine adrenal cortical membranes (IC50 = 7.7 nM), with no effect on AT2 receptors. Tocris Bioscience 4620
      RAAS TargetMol T1518
      Selective non-peptide AT1 antagonist; prodrug of Olmesartan Tocris Bioscience 4620

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.4±0.1 g/cm3
Boiling Point: 804.2±75.0 °C at 760 mmHg
Vapour Pressure: 0.0±3.0 mmHg at 25°C
Enthalpy of Vaporization: 122.6±3.0 kJ/mol
Flash Point: 440.2±37.1 °C
Index of Refraction: 1.661
Molar Refractivity: 149.2±0.5 cm3
#H bond acceptors: 12
#H bond donors: 2
#Freely Rotating Bonds: 11
#Rule of 5 Violations: 3
ACD/LogP: 5.23
ACD/LogD (pH 5.5): 2.82
ACD/BCF (pH 5.5): 39.66
ACD/KOC (pH 5.5): 206.31
ACD/LogD (pH 7.4): 2.15
ACD/BCF (pH 7.4): 8.49
ACD/KOC (pH 7.4): 44.14
Polar Surface Area: 154 Å2
Polarizability: 59.1±0.5 10-24cm3
Surface Tension: 53.7±7.0 dyne/cm
Molar Volume: 403.5±7.0 cm3

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