ChemSpider 2D Image | Metformin hydrochloride | C4H12ClN5

Metformin hydrochloride

  • Molecular FormulaC4H12ClN5
  • Average mass165.625 Da
  • Monoisotopic mass165.078125 Da
  • ChemSpider ID13583

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

Metformin hydrochloride
1,1-Dimethylbiguanide hydrochloride
1115-70-4 [RN]
15537-72-1 [RN]
200-659-6 [EINECS]
214-230-6 [EINECS]
Diamide N,N-diméthylimidodicarbonimidique, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
Imidodicarbonimidic diamide, N,N-dimethyl-, hydrochloride (1:1) [ACD/Index Name]
MFCD00012582 [MDL number]
N,N-Dimethylimidodicarbonimidic diamide hydrochloride (1:1) [ACD/IUPAC Name]
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

DU1800000 [DBID]
AI3-51264 [DBID]
D 15095 [DBID]
D00944 [DBID]
D150959_ALDRICH [DBID]
D5035_SIGMA [DBID]
F2173-0894 [DBID]
HSDB 7080 [DBID]
LS-43900 [DBID]
MLS000028493 [DBID]
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  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      MAPK activator TargetMol T0740

    • Chemical Class:

      A hydrochloride resulting from the reaction of metformin with one molar equivalent of hydrogen chloride. ChEBI https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:6802, CHEBI:6802

    • Bio Activity:

      <p>LKB1/AMPK activator which is blood brain barrier permeable.</p> <p>It improves insulin sensitivity and decreases plasma glucose levels to show antidiabetic activity.</p> <p>Additionally, it displays antiproliferative effects in cancer cell lines, inhibits cancer stem cells (CSCs) and shows anticancer and anti-neoplastic effects. It also promotes neurogenesis by activating the PKC-CBP pathway.</p> <p>Recently investigated as part of COVID-19 compound repurposing.</p> Hello Bio HB2153
      5'-AMP-activated protein kinase TargetMol T0740
      Activator of LKB1/AMPK; antidiabetic agent Tocris Bioscience 2864
      AMPK Tocris Bioscience 2864
      Antidiabetic agent; lowers plasma glucose levels and improves insulin sensitivity. Inhibits hepatic gluconeogenesis via activation of the LKB1/AMPK pathway. Displays antiproliferative effects in cance r cell lines. Activates the aPKC-CBP pathway in neural precursors to promote neurogenesis. Tocris Bioscience 2864
      Antidiabetic agent; lowers plasma glucose levels and improves insulin sensitivity. Inhibits hepatic gluconeogenesis via activation of the LKB1/AMPK pathway. Displays antiproliferative effects in cancer cell lines. Activates the aPKC-CBP pathway in neural precursors to promote neurogenesis. Tocris Bioscience 2864
      Antidiabetic agent; lowers plasma glucose levels and improves insulin sensitivity. Inhibits hepatic gluconeogenesis via activation of the LKB1/AMPK pathway. Displays antiproliferative effects in cancer cell lines. Activates the aPKC-CBP pathway in neural precursors to promote neurogenesis. Activates autophagy. Tocris Bioscience 2864
      Antidiabetic agent; lowers plasma glucose levels and improves insulin sensitivity. Inhibits hepatic gluconeogenesis via activation of the LKB1/AMPK pathway. Displays antiproliferative effects in cancer cell lines. Activates the aPKC-CBP pathway in neural precursors to promote neurogenesis. Activates autophagy. Deuterated analog also available. Tocris Bioscience 2864
      Biochemicals & small molecules/Agonists & activators Hello Bio HB2153
      Cell process/Stem cells/Differentiation Hello Bio HB2153
      Enzymes Tocris Bioscience 2864
      Enzymes/Kinase/AMPK Hello Bio HB2153
      Kinases Tocris Bioscience 2864
      LKB1/AMPK activator. Also promotes neurogenesis. Hello Bio HB2153
      LKB1/AMPK activator. Blood brain barrier permeable. Improves insulin sensitivity and decreases plasma glucose levels to show antidiabetic activity. Also inhibits cancer stem cells (CSCs) and shows anticancer and anti-neoplastic effects. Promotes neurogenesis by activating the PKC-CBP pathway. Hello Bio HB2153
      MAPK Signaling TargetMol T0740
      Metformin Hcl, a widely used anti-diabetic drug has potential efficacy as an anti-cancer drug. MedChem Express http://www.medchemexpress.com/levalbuterol-tartrate.html, HY-17471A
      Metformin Hcl, a widely used anti-diabetic drug has potential efficacy as an anti-cancer drug. Metformin inhibits the proliferation of a range of cancer cells including prostate, colon, breast, ovarian, and glioma lines.;IC50 Value: 2.45 uM (A-ESCs cell); 7.87 uM (N-ESCs cell); 5 mM (PC-3 cell) [1] [3];Target: Anticancer;In vitro: Metformin inhibited proliferation of ESCs in a concentration-dependent manner. The IC50 was 2.45ummol/l for A-ESCs and 7.87ummol/l for N-ESCs. Metformin increased AMPK activation levels (p-AMPK/AMPK) by 2.0?0.3-fold in A-ESCs, 2.3-fold in A-ESCs from the secretory phase, and 1.6-fold in the proliferation phase [1]. Metformin decreased glycogen synthesis in a dose-dependent manner with an IC50 value of 196.5 mM in cultured rat hepatocytes [2]. Average cell viability and cytotoxic effects of metformin were investigated at 24 hour intervals for three days using the xCELLigence system. The IC50 dose of metformin in the PC-3 cells was found to be 5 mM [3].;In MedChem Express HY-17471A
      Others MedChem Express HY-17471A

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

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