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Angiotensin II

Molecular FormulaC₅₀H₇₁N₁₃O₁₂
Average mass1046.179 Da
Monoisotopic mass1045.534546 Da
ChemSpider ID150504

- 9 of 9 defined stereocentres

More details:

Names and Synonyms
Database ID(s)

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(3S)-3-amino-3-[(Z)-[(1S)-4-carbamimidamido-1-[(Z)-[(1S)-1-[(Z)-[(1S)-1-[(Z)-[(1S,2S)-1-[(Z)-[(2S)-1-[(2S)-2-[(Z)-[(1S)-1-carboxy-2-phenylethyl]-C-hydroxycarbonimidoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-C-hydroxycarbonimidoyl]-2-methy

(3S,4E,6S,7E,9S,10E,12S,13E,15S,16S)-3-Amino-6-(3-carbamimidamidopropyl)-15-[(E)-{[(2S)-1-{(2S)-2-[(E)-{[(1S)-1-carboxy-2-phenylethyl]imino}(hydroxy)methyl]-1-pyrrolidinyl}-3-(1H-imidazol-5-yl)-1-oxo- 2-propanyl]imino}(hydroxy)methyl]-4,7,10,13-tetrahydroxy-12-(4-hydroxybenzyl)-9-isopropyl-16-methyl-5,8,11,14-tetraazaoctadeca-4,7,10,13-tetraen-1-oic acid [ACD/IUPAC Name]

32044-01-2 [RN]

5-isoleucine-angiotensin II

5-L-isoleucine-angiotensin II

Acide (3S,4E,6S,7E,9S,10E,12S,13E,15S,16S)-3-amino-6-(3-carbamimidamidopropyl)-15-[(E)-{[(2S)-1-{(2S)-2-[(E)-{[(1S)-1-carboxy-2-phényléthyl]imino}(hydroxy)méthyl]-1-pyrrolidinyl}-3-(1H-imidazol-5-yl)- 1-oxo-2-propanyl]imino}(hydroxy)méthyl]-4,7,10,13-tétrahydroxy-12-(4-hydroxybenzyl)-9-isopropyl-16-méthyl-5,8,11,14-tétraazaoctadéca-4,7,10,13-tétraén-1-oïque [French] [ACD/IUPAC Name]

Angiotensin II [INN] [USAN]

ANGIOTENSIN II-HUMAN

ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE

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Benzenepropanoic acid, α-[[(1E)-[(2S)-1-[(2S,3E,5S,6E,8S,9E,11S,12E,14S)-19-amino-14-[[(1E,2S)-2-amino-3-carboxy-1-hydroxypropylidene]amino]-4,7,10,13-tetrahydroxy-8-[(4-hydroxyphenyl)methyl]-2-(1 H-imidazol-5-ylmethyl)-19-imino-11-(1-methylethyl)-5-[(1S)-1-methylpropyl]-1-oxo-3,6,9,12,18-pentaazanonadeca-3,6,9,12-tetraen-1-yl]-2-pyrrolidinyl]hydroxymethylene]amino]-, (αS)- [ACD/Index Name]

human angiotensinogen (1-8)-peptide

Ile(5)-angiotensin II

Ile(5)-angiotensin II dizwitterion

L-Phenylalanine, L-α-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl- [ACD/Index Name]

L-α-Asparagyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanin [German] [ACD/IUPAC Name]

L-α-Aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanine [ACD/IUPAC Name]

L-α-Aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phénylalanine [French] [ACD/IUPAC Name]

MFCD00161484 [MDL number]

UNII:M089EFU921

(1,2-Dimethyl-1H-imidazol-5-yl)boronic acid [ACD/IUPAC Name]

(3S)-3-amino-3-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S,2S)-1-{[(2S)-1-[(2S)-2-{[(1S)-1-carboxy-2-phenylethyl]carbamoyl}pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]carbamoyl}-2-methylbutyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}-2-methylpropyl]carbamoyl}-4-[(diaminomethylidene)amino]butyl]carbamoyl}propanoic acid

(3S)-3-AMINO-3-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S,2S)-1-{[(2S)-1-[(2S)-2-{[(1S)-1-CARBOXY-2-PHENYLETHYL]CARBAMOYL}PYRROLIDIN-1-YL]-3-(3H-IMIDAZOL-4-YL)-1-OXOPROPAN-2-YL]CARBAMOYL}-2-METHYLBUTYL]CARBAMOYL}-2-(4-HYDROXYPHENYL)ETHYL]CARBAMOYL}-2-METHYLPROPYL]CARBAMOYL}-4-[(DIAMINOMETHYLIDENE)AMINO]BUTYL]CARBAMOYL}PROPANOIC ACID

(3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[(2S)-2-[[[(1S)-1-carboxy-2-phenylethyl]amino]-oxomethyl]-1-pyrrolidinyl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acid

(3S)-3-amino-4-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-hydroxy-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-(3H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopentan-2-yl]amino]-4-oxobutanoic acid

(3S)-3-azaniumyl-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[(2S)-2-[[(1S)-1-carboxylato-2-phenylethyl]carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneazaniumyl)-1-oxopentan-2-yl]amino]-4-oxobutanoate

[ile5]-angiotensin 2

166412-78-8 [RN]

1-8-Angiotensin I

1-L-Aspasaginyl-5-L-valyl angiotensin octapeptide

4289487 [Beilstein]

5-L-isoleucineangiotensin II

Ang II

Angiotensin [Wiki]

angiotensin ???, human

angiotensin ???,human

Angiotensin 2

angiotensin ⅱ, human

Angiotensin II (9CI)

Angiotensin II (human)|5-L-isoleucine-angiotensin II

Angiotensin II,5-L-isoleucine-

angiotensina II

angiotensine II

angiotensinum II

Angiotonin

DRVYIHPF

h-asp-arg-val-tyr-ile-his-pro-phe-oh

human angiotensin II

HYPERTENSIN

Ile5-angiotensin II

isoleucine(5)-angiotensin II

Isoleucine5-angiotensin II

N-(1-(N-(N-(N-(N-(N(2)-L-α-aspartyl-L-arginyl)-L-valyl)-L-tyrosyl)-L-isoleucyl)-L-histidyl)-L-prolyl)-L-phenylalanine

ty-10721

ангиотензин II [Russian]

أنجيوتنسين II [Arabic]

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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

Experimental data
Predicted - ACD/Labs
Predicted - ChemAxon
Predicted - Mcule

Experimental Physico-chemical Properties

Experimental Solubility:

Miscellaneous

Chemical Class:

Bio Activity:

Angiotensin II is a peptide endocrine hormone which is involved in a variety of biological processes. Angiotensin II is the primary effector of the RAS (renin-angiotensin system) which is a central component of the physiological/ pathophysiological responses of the cardiovascular system. Stimulation with angiotensin II modulates blood pressure and regulates vasoconstriction and salt/water homeostasis. Angiotensin II is also associated with induction of smooth muscle cell growth.   Angiotensin II is also involved in the inflammatory process. It is considered a growth factor that regulates cell growth and fibrosis. It increases adhesion molecules, cytokines and chemokines and exerts a proinflammatory effect on various cell types (e.g. leucocytes, endothelial cells and vascular smooth muscle cells). Hello Bio HB3488

7-TM Receptors Tocris Bioscience 1158

Angiotensin Receptors Tocris Bioscience 1158

Endogenous peptide hormone. Potent vasoconstrictor. Hello Bio HB3488

Endogenous potent vasoconstrictor peptide. Stimulates the synthesis and release of aldosterone. Tocris Bioscience 1158

Peptide Receptors Tocris Bioscience 1158

Potent vasoconstrictor peptide Tocris Bioscience 1158

Proteins & peptides Hello Bio HB3488

Receptors & Transporters/Peptide Receptors/Angiotensin Hello Bio HB3488

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density:	1.4±0.1 g/cm³
Boiling Point:	1251.1±75.0 °C at 760 mmHg
Vapour Pressure:	0.0±0.3 mmHg at 25°C
Enthalpy of Vaporization:	195.5±3.0 kJ/mol
Flash Point:	710.4±37.1 °C
Index of Refraction:	1.664
Molar Refractivity:	269.5±0.5 cm³
#H bond acceptors:	25
#H bond donors:	16
#Freely Rotating Bonds:	30
#Rule of 5 Violations:	4

ACD/LogP:	5.72
ACD/LogD (pH 5.5):	-0.22
ACD/BCF (pH 5.5):	1.00
ACD/KOC (pH 5.5):	1.00
ACD/LogD (pH 7.4):	-1.21
ACD/BCF (pH 7.4):	1.00
ACD/KOC (pH 7.4):	1.00
Polar Surface Area:	427 Å²
Polarizability:	106.8±0.5 10^-24cm³
Surface Tension:	61.7±7.0 dyne/cm
Molar Volume:	726.9±7.0 cm³

Click to predict properties on the Chemicalize site

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Angiotensin II

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