ChemSpider 2D Image | Erlotinib hydrochloride | C22H24ClN3O4

Erlotinib hydrochloride

  • Molecular FormulaC22H24ClN3O4
  • Average mass429.897 Da
  • Monoisotopic mass429.145538 Da
  • ChemSpider ID154045

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

183319-69-9 [RN]
4-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-, hydrochloride (1:1) [ACD/Index Name]
Chlorure d'hydrogène - N-(3-éthynylphényl)-6,7-bis(2-méthoxyéthoxy)-4-quinazolinamine (1:1:1) [French] [ACD/IUPAC Name]
Erlotinib HCl
Erlotinib hydrochloride [USAN]
Erlotinib Hydrochloride Salt
Hydrogen chloride - N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine (1:1:1) [ACD/IUPAC Name]
Hydrogenchlorid --N-(3-ethinylphenyl)-6,7-bis(2-methoxyethoxy)-4-chinazolinamin (1:1:1) [German] [ACD/IUPAC Name]
MFCD07781272 [MDL number]
N-(3-Ethinylphenyl)-6,7-bis(2-methoxyethoxy)chinazolin-4-aminhydrochlorid
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

774 hydrochloride [DBID]
CP-358 [DBID]
CP-358774-01 [DBID]
OSI-744 hydrochloride [DBID]
OSI-774 [DBID]
VA0971200 [DBID]
8813963 [DBID]
BR-75676 [DBID]
CP 358774 [DBID]
CP-358774 [DBID]
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  • Miscellaneous

    • Target Organs:

      EGFR inhibitor TargetMol T0373L

    • Chemical Class:

      A quinazoline hydrochloride compound having a (3-ethynylphenyl)amino group at the 4-position and two 2-methoxyethoxy groups at the 6- and 7-positions. ChEBI CHEBI:53509
      The hydrochloride salt of erlotinib. ChEBI CHEBI:53509

    • Bio Activity:

      EGFR MedChem Express HY-12008
      EGFR TargetMol T0373L
      Erlotinib Hcl(NSC 718781; OSI-774; CP-358774) is a directly acting inhibitor of human EGFR tyrosine kinase with an IC50 of 2 nM. MedChem Express
      Erlotinib Hcl(NSC 718781; OSI-774; CP-358774) is a directly acting inhibitor of human EGFR tyrosine kinase with an IC50 of 2 nM.;IC50 Value: 2 nM [1];In vitro: CP-358,774 inhibits the proliferation of DiFi human colon tumor cells at submicromolar concentrations in cell culture and blocks cell cycle progression at the G1 phase. This inhibitor produces a marked accumulation of retinoblastoma protein in its underphosphorylated form and accumulation of p27KIP1 in DiFi cells, which may contribute to the cell cycle block [1]. Erlotinib increased NOX4 mRNA and protein expression by increasing its promoter activity and mRNA stability in FaDu cells [2].;In vivo: At doses of 100 mg/kg, CP-358,774 completely prevents EGF-induced autophosphorylation of EGFR in human HN5 tumors growing as xenografts in athymic mice and of the hepatic EGFR of the treated mice [1]. Erlotinib had no single agent antitumor activity, raised serum-VEGF levels, and lacked a synergistic effect in combination with soraf MedChem Express HY-12008
      JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; MedChem Express HY-12008
      Tyrosine Kinase/Adaptors TargetMol T0373L

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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