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ChemSpider 2D Image | Memantine hydrochloride | C12H22ClN

Memantine hydrochloride

  • Molecular FormulaC12H22ClN
  • Average mass215.763 Da
  • Monoisotopic mass215.144073 Da
  • ChemSpider ID157849

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

Memantine hydrochloride
1-Amino-3,5-dimethyladamantane Hydrochloride
255-219-6 [EINECS]
3,5-Dimethyl-1-adamantanamine hydrochloride (1:1) [ACD/IUPAC Name]
3,5-Diméthyl-1-adamantanamine, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
3,5-Dimethyl-1-adamantanaminhydrochlorid (1:1) [German] [ACD/IUPAC Name]
3,5-Dimethyladamantan-1-amine hydrochloride (1:1)
3,5-diméthyltricyclo[,7]décan-1-amine chlorhydrate
3,5-dimethyltricyclo[,7]decan-1-amine hydrochloride
3,5-dimethyltricyclo[,7]decan-1-amine hydrochloride (1:1)

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

D-145 [DBID]
EU-0100861 [DBID]
MFCD02114015 [DBID]
NMI-131 [DBID]
NSC 102290 [DBID]
  • Experimental Physico-chemical Properties
  • Predicted Physico-chemical Properties
  • Miscellaneous
    • Appearance:

      FINE WHITE POWDER NIH Clinical Collection [SMR000875213]
    • Safety:

      IRRITANT Matrix Scientific 060562
      None LKT Labs [M1749]
    • Target Organs:

      AMPAR inhibitor; NMDAR inhibitor TargetMol T1443
    • Chemical Class:

      A hydrochloride obtained by reaction of memantine with one equivalent of hydrochloric acid. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels. ChEBI CHEBI:64323,
    • Compound Source:

      synthetic Microsource [01501121]
    • Bio Activity:

      <p>Non-competitive NMDA receptor antagonist (IC<sub>50</sub> = 1.25 &mu;M). Binds to ion channel site.</p> <p>Shows low affinity but has rapid blocking and unblocking ability at the NMDAR.</p> <p>Selectively blocks extrasynaptic NMDARs.</p> <p>Enhances hippocampal long-term potentiation (LTP) and reverses LTP suppression.</p> <p>Improves cognitive function and shows anti-Alzheimer's activity.</p> Hello Bio HB0407
      AMPA receptor, Kainate receptor, NMDA receptor TargetMol T1443
      An antagonist at the NMDA receptor, binding to the ion channel site. Used in the treatment of Parkinsonism. Tocris Bioscience 773, 0773
      Biochemicals & small molecules/Antagonists & inhibitors Hello Bio HB0407
      Glutamate (Ionotropic) Receptors Tocris Bioscience 773
      Ion Channels Tocris Bioscience 773
      Ion channels/Ligand-gated ion channel/Ionotropic glutamate receptors/NMDA Hello Bio HB0407
      Ligand-gated Ion Channels Tocris Bioscience 773
      Neuroscience TargetMol T1443
      NMDA antagonist; acts at ion channel site Tocris Bioscience 0773
      Non-competitive NMDA receptor antagonist Hello Bio HB0407

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site