ChemSpider 2D Image | Golvatinib | C33H37F2N7O4

Golvatinib

  • Molecular FormulaC33H37F2N7O4
  • Average mass633.688 Da
  • Monoisotopic mass633.287537 Da
  • ChemSpider ID17275597

More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1,1-Cyclopropanedicarboxamide, N-[2-fluoro-4-[[2-[[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]amino]-4-pyridinyl]oxy]phenyl]-N'-(4-fluorophenyl)- [ACD/Index Name]
516Z3YP58E
928037-13-2 [RN]
9565
E7050
Golvatinib [INN] [USAN]
Golvatinib [Spanish] [INN]
Golvatinib [French] [INN]
Golvatinibum [Latin] [INN]
N-(2-Fluor-4-{[2-({[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl}amino)-4-pyridinyl]oxy}phenyl)-N'-(4-fluorphenyl)-1,1-cyclopropandicarboxamid [German] [ACD/IUPAC Name]
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  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Safety:

      5 Axon Medchem 1959
      H303;H313;H317;H333;H334;H335;H373 Axon Medchem 1959
      no pictogram Axon Medchem 1959
      P101;P102;P103;P260;P262;P263;P264;P270;P280;P304;P312;P340 Axon Medchem 1959
      Warning Axon Medchem 1959
    • Bio Activity:

      c-Met/HGFR MedChem Express HY-13068
      c-Met/HGFR VEGFR MedChem Express HY-13068
      E7050(Golvatinib) is a dual c-Met and VEGFR-2 inhibitor with IC50 of 14 nM and 16 nM. MedChem Express
      E7050(Golvatinib) is a dual c-Met and VEGFR-2 inhibitor with IC50 of 14 nM and 16 nM.; IC50 value: 14/16 nM (c-Met/VEGFR2) [1]; Target: c-Met/VEGFR2; in vitro: In vitro studies indicate that E7050 potently inhibits phosphorylation of both c-Met and VEGFR-2. MedChem Express HY-13068
      E7050(Golvatinib) is a dual c-Met and VEGFR-2 inhibitor with IC50 of 14 nM and 16 nM.;IC50 value: 14/16 nM (c-Met/VEGFR2) [1];Target: c-Met/VEGFR2;In vitro: In vitro studies indicate that E7050 potently inhibits phosphorylation of both c-Met and VEGFR-2. E7050 also potently represses the growth of both c-met amplified tumor cells and endothelial cells stimulated with either HGF or VEGF [1]. E7050 circumvents resistance to all of the reversible, irreversible, and mutant-selective EGFR-TKIs induced by exogenous and/or endogenous HGF in EGFR mutant lung cancer cell lines, by blocking the Met/Gab1/PI3K/Akt pathway in vitro. E7050 also prevents the emergence of gefitinib-resistant HCC827 cells induced by continuous exposure to HGF [2].;In vivo: In vivo studies using E7050 shows inhibition of the phosphorylation of c-Met and VEGFR-2 in tumors, and strong inhibition of tumor growth and tumor angiogenesis in xenograft models. Treatment of some tumor lines containing c-met amplifications w MedChem Express HY-13068
      Protein Tyrosine Kinase/RTK MedChem Express HY-13068
      Protein Tyrosine Kinase/RTK; MedChem Express HY-13068

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.4±0.1 g/cm3
Boiling Point: 867.5±65.0 °C at 760 mmHg
Vapour Pressure: 0.0±3.3 mmHg at 25°C
Enthalpy of Vaporization: 126.1±3.0 kJ/mol
Flash Point: 478.5±34.3 °C
Index of Refraction: 1.671
Molar Refractivity: 168.2±0.3 cm3
#H bond acceptors: 11
#H bond donors: 3
#Freely Rotating Bonds: 8
#Rule of 5 Violations: 2
ACD/LogP: 2.03
ACD/LogD (pH 5.5): -0.41
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.00
ACD/LogD (pH 7.4): 1.46
ACD/BCF (pH 7.4): 4.63
ACD/KOC (pH 7.4): 57.56
Polar Surface Area: 119 Å2
Polarizability: 66.7±0.5 10-24cm3
Surface Tension: 70.6±3.0 dyne/cm
Molar Volume: 450.0±3.0 cm3

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