ChemSpider 2D Image | Exenatide | C184H282N50O60S

Exenatide

  • Molecular FormulaC184H282N50O60S
  • Average mass Da
  • Monoisotopic mass Da
  • ChemSpider ID17314184
  • defined stereocentres - 37 of 37 defined stereocentres


More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

141732-76-5 [RN]
exenatida [Spanish] [INN]
exénatide [French] [INN]
exenatidum [Latin] [INN]
Exendin-4
L-histidylglycyl-L-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-aspartyl-L-leucyl-L-seryl-L-lysyl-L-glutaminyl-L-methionyl-L-glutamyl-L-glutamyl-L-glutamyl-L-alanyl-L-valyl-L-arginyl-L-leucyl-L-phenylalanyl-L-isoleucyl-L-glutamyl-L-tryptophyl-L-leucyl-L-lysyl-L-asparaginylglycylglycyl-L-prolyl-L-seryl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-L-serinamide
эксенатид [Russian] [INN]
إيكزاناتيد [Arabic] [INN]
艾塞那肽 [Chinese] [INN]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

AC 2993 [DBID]
AC002993 [DBID]
AC2993 [DBID]
AC-2993 [DBID]
AC2993A [DBID]
LY2148568 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Drug Status:

      approved BIONET-Key Organics HS-2012
    • Bio Activity:

      7-TM Receptors Tocris Bioscience 1933
      Exendin-4(Exenatide), a 39 amino acid peptide, activates GLP-1 (glucagon-like peptide-1) receptors to increase intracellular cAMP in pancreatic acinar cells and has no effect on VIP receptors. ;IC50 Value:;Target: Glucagon ReceptorExendin-4 stimulates proliferation of HCAECs through PKA-PI3K/Akt-eNOS activation pathways via a GLP-1(glucagon-like peptide-1) receptor-dependent mechanism. Exendin-4, the long-acting GLP-1 receptor agonist, is an incretin mimetic approved for type 2 diabetes mellitus treatment. Studies also demonstrated its neurotrophic/protective activity in cellular and animal models of stroke, Alzheimer's and Parkinson's diseases. MedChem Express HY-13443
      Glucagon and Related Peptide Receptors Tocris Bioscience 1933
      Glucagon Receptor MedChem Express HY-13443
      GPCR/G protein; MedChem Express HY-13443
      High affinity glucagon-like peptide 1 (GLP-1) receptor agonist (Kd = 136 pM); originally isolated from Heloderma suspectum venom. Potently induces cAMP formation without stimulating amylase release in pancreatic acini. Potentiates glucose-induced insulin secretion in isolated rat islets. Protects against glutamate-induced neurotoxicity. Tocris Bioscience 1933
      High affinity glucagon-like peptide 1 (GLP-1) receptor agonist (Kd = 136 pM); originally isolated from Heloderma suspectum venom. Potently induces cAMP formation without stimulating amylase release in pancreatic acini. Potentiates glucose-induced insulin secretion in isolated rat islets. Protects against glutamate-induced neurotoxicity. Tocris Bioscience 1933
      Peptide Receptors Tocris Bioscience 1933
      Potent GLP-1 receptor agonist Tocris Bioscience 1933

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

No predicted properties have been calculated for this compound.

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