ChemSpider 2D Image | Conivaptan hydrochloride | C32H27ClN4O2

Conivaptan hydrochloride

  • Molecular FormulaC32H27ClN4O2
  • Average mass535.035 Da
  • Monoisotopic mass534.182251 Da
  • ChemSpider ID187511

More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

[1,1'-Biphenyl]-2-carboxamide, N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-, hydrochloride (1:1) [ACD/Index Name]
[1,1'-biphenyl]-2-carboxamide, N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-, monohydrochloride
168626-94-6 [RN]
75L57R6X36
Conivaptan HCl
Conivaptan hydrochloride [JAN] [USAN]
N-{4-[(2-Methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl}-2-biphenylcarboxamide hydrochloride (1:1) [ACD/IUPAC Name]
N-{4-[(2-Méthyl-4,5-dihydroimidazo[4,5-d][1]benzazépin-6(1H)-yl)carbonyl]phényl}-2-biphénylcarboxamide, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
N-{4-[(2-Methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl}-2-biphenylcarboxamidhydrochlorid (1:1) [German] [ACD/IUPAC Name]
N-{4-[(2-méthyl-4,5-dihydroimidazo[4,5-d][1]benzazépin-6(1H)-yl)carbonyl]phényl}biphényl-2-carboxamide chlorhydrate [French]
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

8667691 [DBID]
CI-1025 [DBID]
D01236 [DBID]
YM 087 [DBID]
YM-087 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Chemical Class:

      The hydrochloride salt of conivaptan. It is an antagonist for two of the three types of arginine vasopressin (AVP) receptors, V<smallsub>1a</smallsub> and V<smallsub>2</smallsub>, and is used for the treatment of hyponatraemia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). ChEBI CHEBI:31430
      The hydrochloride salt of conivaptan. It is an antagonist for two of the three types of arginine vasopressin (AVP) receptors, V1a and V2, and is used for the treatment of hyponatraemia (low blood sodi um levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). ChEBI CHEBI:31430
    • Bio Activity:

      Conivaptan(YM 087) is a non-peptide inhibitor of antidiuretic hormone (vasopressin receptor antagonist) with Ki values of 0.48 and 3.04 nM for rat liver V1A receptor and rat kidney V2 receptor respect ively. MedChem Express
      Conivaptan(YM 087) is a non-peptide inhibitor of antidiuretic hormone (vasopressin receptor antagonist) with Ki values of 0.48 and 3.04 nM for rat liver V1A receptor and rat kidney V2 receptor respectively.; IC50 value: 0.48 nM (Rat liver V1A receptor); 3.04 nM (Rat kidney V2 receptor) [1]; in vitro: YM087 showed high affinity for V1A receptors from rat liver and V2 receptors from rat kidney with Ki values of 0.48 and 3.04 nM, respectively. MedChem Express HY-18347A
      Conivaptan(YM 087) is a non-peptide inhibitor of antidiuretic hormone (vasopressin receptor antagonist) with Ki values of 0.48 and 3.04 nM for rat liver V1A receptor and rat kidney V2 receptor respectively.;IC50 value: 0.48 nM (Rat liver V1A receptor); 3.04 nM (Rat kidney V2 receptor) [1];In vitro: YM087 showed high affinity for V1A receptors from rat liver and V2 receptors from rat kidney with Ki values of 0.48 and 3.04 nM, respectively. YM087 also inhibited [3H]oxytocin (OT) binding to rat uterus (OT receptors) plasma membranes with a Ki value of 44.4 nM, and at 100 microM did not affect the binding of [3H]AVP to anterior pituitary (V1B receptors) plasma membranes, which indicated that it had less affinity for these OT and V1B receptors [1].YM087 potently blocked AVP-induced cAMP production of cultured renal epithelium cells concentration dependently and had no agonistic activities. YM087 showed high affinity for cardiomyocyte V1A receptors with a Ki value of 0.63 nM. In these sam MedChem Express HY-18347A
      GPCR/G protein MedChem Express HY-18347A
      GPCR/G protein; MedChem Express HY-18347A
      Vasopressin Receptor MedChem Express HY-18347A

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

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