ChemSpider 2D Image | IDALOPIRDINE HYDROCHLORIDE | C20H20ClF5N2O

IDALOPIRDINE HYDROCHLORIDE

  • Molecular FormulaC20H20ClF5N2O
  • Average mass434.831 Da
  • Monoisotopic mass434.118439 Da
  • ChemSpider ID19878970

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1H-Indole-3-ethanamine, 6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]methyl]-, hydrochloride (1:1) [ACD/Index Name]
2-(6-Fluor-1H-indol-3-yl)-N-[3-(2,2,3,3-tetrafluorpropoxy)benzyl]ethanaminhydrochlorid (1:1) [German] [ACD/IUPAC Name]
2-(6-Fluoro-1H-indol-3-yl)-N-[3-(2,2,3,3-tetrafluoropropoxy)benzyl]ethanamine hydrochloride (1:1) [ACD/IUPAC Name]
2-(6-Fluoro-1H-indol-3-yl)-N-[3-(2,2,3,3-tétrafluoropropoxy)benzyl]éthanamine, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
467458-02-2 [RN]
IDALOPIRDINE HYDROCHLORIDE
[2-(6-fluoro-1H-indol-3-yl)ethyl]({[3-(2,2,3,3-tetrafluoropropoxy)phenyl]methyl})amine hydrochloride
14024-61-4 [RN]
2-(6-fluoro-1H-indol-3-yl)-N-(3-(2,2,3,3-tetrafluoropropoxy)benzyl)ethan-1-amine hydrochloride
2-(6-fluoro-1H-indol-3-yl)-N-(3-(2,2,3,3-tetrafluoropropoxy)benzyl)ethanamine hydrochloride
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

545BT5182Y [DBID]
PubChem Substance ID 329825761 [DBID]
UNII:545BT5182Y [DBID]
UNII-545BT5182Y [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      5-HT Receptor MedChem Express HY-14338A
      GPCR/G protein MedChem Express HY-14338A
      GPCR/G protein; Neuronal Signaling; MedChem Express HY-14338A
      Lu AE58054 hydrochloride is an in-vitro potency and selectivity, in-vivo binding affinity and effect of the 5-HT(6)R antagonist with a Ki value of 0.83 nM. MedChem Express
      Lu AE58054 hydrochloride is an in-vitro potency and selectivity, in-vivo binding affinity and effect of the 5-HT(6)R antagonist with a Ki value of 0.83 nM.; IC50 Value: 0.83 nm [1]; Target: 5-HT(6)R; in vitro: Lu AE58054 displayed high affinity to the human 5-HT(6) receptor (5-HT(6)R) with a Ki of 0.83 nm. MedChem Express HY-14338A
      Lu AE58054 hydrochloride is an in-vitro potency and selectivity, in-vivo binding affinity and effect of the 5-HT(6)R antagonist with a Ki value of 0.83 nM.;IC50 Value: 0.83 nm [1];Target: 5-HT(6)R;In vitro: Lu AE58054 displayed high affinity to the human 5-HT(6) receptor (5-HT(6)R) with a Ki of 0.83 nm. In a 5-HT(6) GTPgammaS efficacy assay Lu AE58054 showed no agonist activity, but demonstrated potent inhibition of 5-HT-mediated activation. Besides medium affinity to adrenergic alpha(1A)- and alpha(1B)-adrenoreceptors, Lu AE58054 demonstrated >50-fold selectivity for more than 70 targets examined [1].;In vivo: Orally administered Lu AE58054 potently inhibited striatal in-vivo binding of the 5-HT(6) antagonist radioligand [(3)H]Lu AE60157, with an ED(50) of 2.7 mg/kg. Steady-state modelling of an acute pharmacokinetic/5-HT(6)R occupancy time-course experiment indicated a plasma EC(50) value of 20 ng/ml. Administration of Lu AE58054 in a dose range (5-20 mg/kg p.o.) leading to abov MedChem Express HY-14338A

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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