ChemSpider 2D Image | Bis-choline tetrathiomolybdate | C10H28MoN2O2S4

Bis-choline tetrathiomolybdate

  • Molecular FormulaC10H28MoN2O2S4
  • Average mass432.542 Da
  • Monoisotopic mass434.008759 Da
  • ChemSpider ID19906891
  • Charge - Charge


More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

649749-10-0 [RN]
Bis(2-hydroxy-N,N,N-trimethylethanaminium) disulfido(dithioxo)molybdenum [ACD/IUPAC Name]
Bis(2-hydroxy-N,N,N-trimethylethanaminium)disulfido(dithioxo)molybdaen [German] [ACD/IUPAC Name]
Bis-choline tetrathiomolybdate [Trade name] [Wiki]
Disulfydo(dithioxo)molybdène de bis(2-hydroxy-N,N,N-triméthyléthanaminium) [French] [ACD/IUPAC Name]
FD57A79R4P
Wtx-101
WTX101
ATN 224
ATN224
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Bio Activity:

      ATN-224(tetrathiomolybdate) is a copper-chelator agent which can inhibit intracellular SOD1 activity with IC50 of 17.5 nM.; IC50 value: 17.5 nM [1]; Target: SOD1; in vitro: ATN-224 inhibits superoxide dismutase 1 (SOD1) in tumor and endothelial cells. MedChem Express HY-16074
      ATN-224(tetrathiomolybdate) is a copper-chelator agent which can inhibit intracellular SOD1 activity with IC50 of 17.5 nM.;IC50 value: 17.5 nM [1];Target: SOD1;In vitro: ATN-224 inhibits superoxide dismutase 1 (SOD1) in tumor and endothelial cells. The inhibition of SOD1 leads to inhibition of endothelial cell proliferation in vitro and attenuation of angiogenesis in vivo. The inhibition of SOD1 activity in endothelial cells is dose and time dependent and leads to an increase in the steady-state levels of superoxide anions, resulting in the inhibition of extracellular signal-regulated kinase phosphorylation without apparent induction of apoptosis [1]. ATN-224 (choline tetrathiomolybdate) can induce cell death in oxidative stress-resistant cells and cells overexpressing Bcl-2 by modulating the cellular redox environment and causing mitochondrial dysfunction. ATN-224 treatment decreases superoxide dismutase 1 (SOD1) activity, increases intracellular oxidants, and induces peroxynitrit MedChem Express HY-16074
      Others MedChem Express HY-16074

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site





Feedback Form