ChemSpider 2D Image | Y-27632 dihydrochloride | C14H23Cl2N3O

Y-27632 dihydrochloride

  • Molecular FormulaC14H23Cl2N3O
  • Average mass320.258 Da
  • Monoisotopic mass319.121826 Da
  • ChemSpider ID19980551
  • defined stereocentres - 3 of 3 defined stereocentres


More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(R)-(+)-trans-4-(1-Aminoethyl)-N-(4-Pyridyl)cyclohexanecarboxamide dihydrochloride
129830-38-2 [RN]
Cyclohexanecarboxamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, trans-, hydrochloride (1:2) [ACD/Index Name]
MFCD03490488 [MDL number]
trans-4-[(1R)-1-Aminoethyl]-N-(4-pyridinyl)cyclohexancarboxamiddihydrochlorid [German] [ACD/IUPAC Name]
trans-4-[(1R)-1-Aminoethyl]-N-(4-pyridinyl)cyclohexanecarboxamide dihydrochloride [ACD/IUPAC Name]
trans-4-[(1R)-1-Aminoéthyl]-N-(4-pyridinyl)cyclohexanecarboxamide, dichlorhydrate [French] [ACD/IUPAC Name]
trans-4-[(1R)-1-Aminoethyl]-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride
Y-27632 dihydrochloride
(1R)-4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-1-carboxamide dihydrochloride
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

Q9828II7F3 [DBID]
UNII:Q9828II7F3 [DBID]
Y 27632 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Safety:

      5 Axon Medchem 1683
      H303;H313;H317;H333;H334;H335;H373 Axon Medchem 1683
      no pictogram Axon Medchem 1683
      P101;P102;P103;P260;P262;P263;P264;P270;P280;P304;P312;P340 Axon Medchem 1683
      Warning Axon Medchem 1683
    • Bio Activity:

      Cell Cycle/DNA Damage MedChem Express HY-10583
      Cell Cycle/DNA Damage; TGF-beta/Smad; MedChem Express HY-10583
      Enzymes Tocris Bioscience 1254
      Kinases Tocris Bioscience 1254
      Rho-kinases Tocris Bioscience 1254
      ROCK MedChem Express HY-10583
      Selective p160ROCK inhibitor Tocris Bioscience 1254
      Selective p160ROCK inhibitor (Ki values are 0.14, 26, 25 and > 250 ?M for p160ROCK, PKC, PKA and MLCK respectively). Also inhibits PRK2 (IC50 = 600 nM). Smooth muscle relaxant and orally active in viv o. Increases survival rate of human embryonic stem (hES) cells undergoing cryopreservation. Also optimizes naïve human pluripotent stem cell growth and viability following naïve cell derivation from p rimed ESCs and iPSCs using naïve human stem cell medium (NHSM). Tocris Bioscience 1254
      Selective p160ROCK inhibitor (Ki values are 0.14, 26, 25 and > 250 ?M for p160ROCK, PKC, PKA and MLCK respectively). Also inhibits PRK2 (IC50 = 600 nM). Smooth muscle relaxant and orally active in vivo. Increases survival rate of human embryonic stem (hES) cells undergoing cryopreservation. Also optimizes na?ve human pluripotent stem cell growth and viability following na?ve cell derivation from primed ESCs and iPSCs using na?ve human stem cell medium (NHSM). Tocris Bioscience 1254
      Selective p160ROCK inhibitor (Ki values are 0.14, 26, 25 and > 250 muM for p160ROCK, PKC, PKA and MLCK respectively). Also inhibits PRK2 (IC50 = 600 nM). Smooth muscle relaxant and orally active in vivo. Increases survival rate of human embryonic stem (hES) cells and iPSC-BMECs undergoing cryopreservation. Also optimizes na?ve human pluripotent stem cell growth and viability following na?ve cell derivation from primed ESCs and iPSCs using na?ve human stem cell medium (NHSM). Tocris Bioscience 1254
      Y-27632 2Hcl is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.; IC50 value: 140 nM (Ki); Target: ROCK1; in vitro: Y-27632 inhibits ROCK-II while displaying little activity against PKC, cAMP-dependent protein kinase and myosin light-chain kinase (MLCK) with Ki of 26 ?M, 25 ?M and > 250 ?M, respectively, as well as PKA activated by another Rho-family GTPase member, Cdc42. MedChem Express HY-10583

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

No predicted properties have been calculated for this compound.

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