ChemSpider 2D Image | Linsitinib | C26H23N5O

Linsitinib

  • Molecular FormulaC26H23N5O
  • Average mass421.494 Da
  • Monoisotopic mass421.190247 Da
  • ChemSpider ID21391708

More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

15A52GPT8T
867160-71-2 [RN]
9357
cis-3-[8-Amino-1-(2-phenyl-7-chinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutanol [German] [ACD/IUPAC Name]
cis-3-[8-Amino-1-(2-phényl-7-quinoléinyl)imidazo[1,5-a]pyrazin-3-yl]-1-méthylcyclobutanol [French] [ACD/IUPAC Name]
cis-3-[8-Amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutanol [ACD/IUPAC Name]
Cyclobutanol, 3-[8-amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methyl-, cis- [ACD/Index Name]
(1s,3s)-3-(8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-1-methylcyclobutan-1-ol
(1s,3s)-3-(8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-1-methylcyclobutanol
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

OSI 906 [DBID]
OSI-906 [DBID]
OSI-906AA [DBID]
PubChem Substance ID 329825761 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Safety:

      5 Axon Medchem 1702
      H303;H313;H317;H333;H334;H335;H373 Axon Medchem 1702
      no pictogram Axon Medchem 1702
      P101;P102;P103;P260;P262;P263;P264;P270;P280;P304;P312;P340 Axon Medchem 1702
      Warning Axon Medchem 1702
    • Bio Activity:

      IGF-1R MedChem Express HY-10191
      IGF-1R Insulin Receptor MedChem Express HY-10191
      Linsitinib(OSI-906) is highly potent, orally efficacious and highly selective, dual ATP-competitive inhibitor of IGF-1R (IC50= 35 nM) and insulin receptor (IC50=75 nM).; IC50 value: 35 nM (IGF-1R); 75 nM (InsR) [1]; Target: IGF-1R;InsR; in vitro: OSI-906 inhibits IGF-1R autophosphorylation and activation of the downstream signaling proteins Akt, ERK1/2 and S6 kinase with IC50 of 0.028 to 0.13 ?M. MedChem Express HY-10191
      Protein Tyrosine Kinase/RTK MedChem Express HY-10191
      Protein Tyrosine Kinase/RTK; MedChem Express HY-10191

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.4±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.748
Molar Refractivity: 123.3±0.5 cm3
#H bond acceptors: 6
#H bond donors: 3
#Freely Rotating Bonds: 3
#Rule of 5 Violations: 0
ACD/LogP: 3.23
ACD/LogD (pH 5.5): 2.33
ACD/BCF (pH 5.5): 23.40
ACD/KOC (pH 5.5): 207.01
ACD/LogD (pH 7.4): 3.03
ACD/BCF (pH 7.4): 117.42
ACD/KOC (pH 7.4): 1038.83
Polar Surface Area: 89 Å2
Polarizability: 48.9±0.5 10-24cm3
Surface Tension: 59.8±7.0 dyne/cm
Molar Volume: 303.2±7.0 cm3

Click to predict properties on the Chemicalize site





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