ChemSpider 2D Image | memantine | C12H22ClN

memantine

  • Molecular FormulaC12H22ClN
  • Average mass215.763 Da
  • Monoisotopic mass215.144073 Da
  • ChemSpider ID21395707

  • defined stereocentres - 4 of 4 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(1r,3R,5S,7r)-3,5-Dimethyl-1-adamantanamine hydrochloride (1:1) [ACD/IUPAC Name]
(1r,3R,5S,7r)-3,5-Diméthyl-1-adamantanamine, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
(1r,3R,5S,7r)-3,5-Dimethyl-1-adamantanaminhydrochlorid (1:1) [German] [ACD/IUPAC Name]
(1r,3R,5S,7r)-3,5-Dimethyladamantan-1-amine hydrochloride (1:1)
255-219-6 [EINECS]
3,5-Dimethyl-1-adamantanamine Hydrochloride
3,5-Dimethylamantadine hydrochloride
3,5-dimethyltricyclo[3.3.1.13,7]decan-1-amine hydrochloride
memantine [INN] [Wiki]
Memantine (hydrochloride)
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Memantine, an amantadine derivative with low to moderate-affinity for NMDA receptors, is used for the treatment of Alzheimer's disease. MedChem Express
      Memantine, an amantadine derivative with low to moderate-affinity for NMDA receptors, is used for the treatment of Alzheimer's disease.; Target: NMDA Receptor; Memantine (Ebixa, Axura, Namenda, Akatinol) is a moderate-affinity, uncompetitive, voltage-dependent, NMDA-receptor antagonist with fast on/off kinetics that inhibits excessive calcium influx induced by chronic overstimulation of the NMDA receptor. MedChem Express HY-B0365A
      Memantine, an amantadine derivative with low to moderate-affinity for NMDA receptors, is used for the treatment of Alzheimer's disease.;Target: NMDA ReceptorMemantine (Ebixa, Axura, Namenda, Akatinol) is a moderate-affinity, uncompetitive, voltage-dependent, NMDA-receptor antagonist with fast on/off kinetics that inhibits excessive calcium influx induced by chronic overstimulation of the NMDA receptor. Memantine is approved in the US and the EU for the treatment of patients with moderate to severe dementia of the Alzheimer's type [1]. Memantine has considerable therapeutic potential for the myriad of clinical entities associated with NMDA receptor-mediated neurotoxicity [2]. Memantine blocked 200 microM NMDA-evoked responses with a 50% inhibition constant (IC50) of approximately 1 microM at -60 mV and an empirical Hill coefficient of approximately 1 [3]. MedChem Express HY-B0365A
      Membrane Tranporter/Ion Channel MedChem Express HY-B0365A
      Membrane Tranporter/Ion Channel; Neuronal Signaling; MedChem Express HY-B0365A
      NMDA Receptor MedChem Express HY-B0365A

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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