ChemSpider 2D Image | BMS-777607 | C25H19ClF2N4O4

BMS-777607

  • Molecular FormulaC25H19ClF2N4O4
  • Average mass512.893 Da
  • Monoisotopic mass512.106262 Da
  • ChemSpider ID21437043

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1025720-94-8 [RN]
1196681-44-3 [RN]
3-Pyridinecarboxamide, N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-1,2-dihydro-2-oxo- [ACD/Index Name]
BMS-777607
BMS-817378
MFCD16495773
N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-1,2-dihydro-2-oxo-3-pyridinecarboxamide
N-{4-[(2-Amino-3-chlor-4-pyridinyl)oxy]-3-fluorphenyl}-4-ethoxy-1-(4-fluorphenyl)-2-oxo-1,2-dihydro-3-pyridincarboxamid [German] [ACD/IUPAC Name]
N-{4-[(2-Amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl}-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydro-3-pyridinecarboxamide [ACD/IUPAC Name]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

A3MMS6HDO1 [DBID]
1025720-94-8/1196681-44-3 [DBID]
353 [DBID]
UNII:A3MMS6HDO1 [DBID]
UNII-A3MMS6HDO1 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      c-Met inhibitor TargetMol T2658, T2699
      c-Met inhibitor;TAM Receptor inhibitor TargetMol T2658, T2699

    • Bio Activity:

      Axl MedChem Express HY-12076
      Axl c-Met/HGFR MedChem Express HY-12076
      BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, 40-fold more selective for Met-related targets versus Lck, VEGFR-2, and TrkA/B, and more than 500-fold greater selectivity versus all other receptor and non receptor kinases. MedChem Express
      BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, 40-fold more selective for Met-related targets versus Lck, VEGFR-2, and TrkA/B, and more than 500-fold greater selectivity versus all other receptor and non receptor kinases.; IC50 value: 3.9/1.1/1.8/4.3 nM (c-Met/Axl/Ron/Tyro3) [1]; Target: c-Met/Axl/Ron/Tyro3; in vitro: BMS-777607 is a selective ATP-competitive Met kinase inhibitor which potently blocks the autophosphorylation of c-Met with IC50 of 20 nM in GTL-16 cell lysates, and demonstrates selective inhibition of proliferation in Met-driven tumor cell lines, such as GTL-16 cell line, H1993 and U87 [1]. MedChem Express HY-12076
      BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, 40-fold more selective for Met-related targets versus Lck, VEGFR-2, and TrkA/B, and more than 500-fold greater selectivity versus all other receptor and non receptor kinases.;IC50 value: 3.9/1.1/1.8/4.3 nM (c-Met/Axl/Ron/Tyro3) [1];Target: c-Met/Axl/Ron/Tyro3;In vitro: BMS-777607 is a selective ATP-competitive Met kinase inhibitor which potently blocks the autophosphorylation of c-Met with IC50 of 20 nM in GTL-16 cell lysates, and demonstrates selective inhibition of proliferation in Met-driven tumor cell lines, such as GTL-16 cell line, H1993 and U87 [1]. BMS-777607 inhibits hepatocyte growth factor (HGF)-triggered c-Met autophosphorylation with IC50 of <1 nM in PC-3 and DU145 prostate cancer cells. BMS 777607 has little effect on tumor cell growth, but exhibits inhibitory effect on HGF-induced cell scattering in PC-3 and DU145 cells, with almost complete inhibition MedChem Express HY-12076
      c-Met;Axl;Ron;Tyro3;Mer; FLT3; Aurora B; LCK; VEGFR2; TrkB; TrkA; PKA; BTK TargetMol T2658, T2699
      Met/Axl/RON/Tyro3 TargetMol T2658, T2699
      Protein Tyrosine Kinase/RTK MedChem Express HY-12076
      Protein Tyrosine Kinase/RTK; MedChem Express HY-12076
      Tyrosine Kinase/Adaptors TargetMol T2658, T2699

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.5±0.1 g/cm3
Boiling Point: 667.9±55.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.0 mmHg at 25°C
Enthalpy of Vaporization: 98.2±3.0 kJ/mol
Flash Point: 357.7±31.5 °C
Index of Refraction: 1.672
Molar Refractivity: 128.3±0.4 cm3
#H bond acceptors: 8
#H bond donors: 3
#Freely Rotating Bonds: 7
#Rule of 5 Violations: 1
ACD/LogP: 4.86
ACD/LogD (pH 5.5): 3.53
ACD/BCF (pH 5.5): 283.24
ACD/KOC (pH 5.5): 1962.66
ACD/LogD (pH 7.4): 3.55
ACD/BCF (pH 7.4): 292.29
ACD/KOC (pH 7.4): 2025.39
Polar Surface Area: 107 Å2
Polarizability: 50.8±0.5 10-24cm3
Surface Tension: 69.7±5.0 dyne/cm
Molar Volume: 342.4±5.0 cm3

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