PLANNED MAINTENANCE

There will be scheduled maintenance work beginning on Wednesday 26th February 2020 from 11:00 AM through to 12.00 PM (GMT).

During this time, you may not be able to log into ChemSpider. We apologise for any inconvenience this might cause and thank you for your patience.


ChemSpider 2D Image | Pictilisib | C23H27N7O3S2

Pictilisib

  • Molecular FormulaC23H27N7O3S2
  • Average mass513.636 Da
  • Monoisotopic mass513.161682 Da
  • ChemSpider ID21437049

More details:



Featured data source



Validated by Experts, Validated by Users, Non-Validated, Removed by Users

2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidine
2-(1H-Indazol-4-yl)-6-{[4-(methylsulfonyl)-1-piperazinyl]methyl}-4-(4-morpholinyl)thieno[3,2-d]pyrimidin [German] [ACD/IUPAC Name]
2-(1H-Indazol-4-yl)-6-{[4-(methylsulfonyl)-1-piperazinyl]methyl}-4-(4-morpholinyl)thieno[3,2-d]pyrimidine [ACD/IUPAC Name]
2-(1H-Indazol-4-yl)-6-{[4-(méthylsulfonyl)-1-pipérazinyl]méthyl}-4-(4-morpholinyl)thiéno[3,2-d]pyrimidine [French] [ACD/IUPAC Name]
2-(1H-Indazol-4-yl)-6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin
9417
957054-30-7 [RN]
GDC 0941
GDC0941
GDC-0941
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Safety:

      IRRITANT Matrix Scientific 093506
    • Target Organs:

      PI3K inhibitor TargetMol T1994
    • Chemical Class:

      A sulfonamide composed of indazole, morpholine, and methylsulfonyl-substituted piperazine rings bound to a thienopyrimidine ring. ChEBI CHEBI:65326
    • Bio Activity:

      GDC-0941 is a potent inhibitor of PI3K?/? with IC50 of 3 nM, with modest selectivity against p110? (11-fold) and p110? (25-fold).; IC50 value: 3 nM; Target: PI3K?/?; GDC-0941 is a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer. MedChem Express HY-50094
      PI3K MedChem Express HY-50094
      PI3K/Akt/mTOR MedChem Express HY-50094
      PI3K/Akt/mTOR ; MedChem Express HY-50094
      PI3K/Akt/mTOR Signaling TargetMol T1994
      PI3K??/??;p110??/p110?? TargetMol T1994

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.5±0.1 g/cm3
Boiling Point: 687.7±65.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.1 mmHg at 25°C
Enthalpy of Vaporization: 100.8±3.0 kJ/mol
Flash Point: 369.7±34.3 °C
Index of Refraction: 1.753
Molar Refractivity: 136.5±0.4 cm3
#H bond acceptors: 10
#H bond donors: 1
#Freely Rotating Bonds: 5
#Rule of 5 Violations: 2
ACD/LogP: 2.04
ACD/LogD (pH 5.5): 1.80
ACD/BCF (pH 5.5): 13.26
ACD/KOC (pH 5.5): 211.65
ACD/LogD (pH 7.4): 1.87
ACD/BCF (pH 7.4): 15.49
ACD/KOC (pH 7.4): 247.25
Polar Surface Area: 144 Å2
Polarizability: 54.1±0.5 10-24cm3
Surface Tension: 93.3±5.0 dyne/cm
Molar Volume: 333.8±5.0 cm3

Click to predict properties on the Chemicalize site






Advertisement