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Search term: COc1ccc2c(ccnc2c1)OCc3nnc4n3nc(cc4)c5ccccc5 (Found by conversion of search term to chemical structure (full match))

ChemSpider 2D Image | AMG-208 | C22H17N5O2


  • Molecular FormulaC22H17N5O2
  • Average mass383.403 Da
  • Monoisotopic mass383.138214 Da
  • ChemSpider ID21486186

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1002304-34-8 [RN]
7-Methoxy-4-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy]chinolin [German] [ACD/IUPAC Name]
7-Méthoxy-4-[(6-phényl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)méthoxy]quinoléine [French] [ACD/IUPAC Name]
7-Methoxy-4-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline [ACD/IUPAC Name]
Quinoline, 7-methoxy-4-[(6-phenyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl)methoxy]- [ACD/Index Name]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Safety:

      5 Axon Medchem 1916
      H303;H313;H317;H333;H334;H335;H373 Axon Medchem 1916
      no pictogram Axon Medchem 1916
      P101;P102;P103;P260;P262;P263;P264;P270;P280;P304;P312;P340 Axon Medchem 1916
      Warning Axon Medchem 1916
    • Chemical Class:

      A member of the class of quinolines that is 7-methoxyquinoline substituted at position 4 by a (6-phenyl[1,2,4]triazolo[4,3-<ital>b</ital>]pyridazin-3-yl)methoxy group. AMG exhibits antitumour activity , particularly in prostate cancer. ChEBI CHEBI:90626
    • Bio Activity:

      AMG-208 is a potent small molecular c-Met inhibitor with an IC50 of 9.3 nM.; IC50 value: 9.3 nM; Target: c-Met; in vitro: AMG-208 shows the potent inhibition of kinase c-Met activity with IC50 of 9 nM in a cell-free assay. MedChem Express HY-12035
      c-Met/HGFR MedChem Express HY-12035
      Protein Tyrosine Kinase/RTK MedChem Express HY-12035
      Protein Tyrosine Kinase/RTK; MedChem Express HY-12035

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.3±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.696
Molar Refractivity: 110.0±0.5 cm3
#H bond acceptors: 7
#H bond donors: 0
#Freely Rotating Bonds: 5
#Rule of 5 Violations: 0
ACD/LogP: 4.02
ACD/LogD (pH 5.5): 2.91
ACD/BCF (pH 5.5): 72.12
ACD/KOC (pH 5.5): 534.82
ACD/LogD (pH 7.4): 3.40
ACD/BCF (pH 7.4): 224.22
ACD/KOC (pH 7.4): 1662.75
Polar Surface Area: 74 Å2
Polarizability: 43.6±0.5 10-24cm3
Surface Tension: 53.8±7.0 dyne/cm
Molar Volume: 285.7±7.0 cm3

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