ChemSpider 2D Image | PFI-4 | C21H24N4O3

PFI-4

  • Molecular FormulaC21H24N4O3
  • Average mass380.440 Da
  • Monoisotopic mass380.184845 Da
  • ChemSpider ID21625922

More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

900305-37-5 [RN]
Benzamide, N-[2,3-dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxy- [ACD/Index Name]
N-(1,3-dimethyl-2-oxo-6-pyrrolidin-1-ylbenzimidazol-5-yl)-2-methoxybenzamide
N-[1,3-Dimethyl-2-oxo-6-(1-pyrrolidinyl)-2,3-dihydro-1H-benzimidazol-5-yl]-2-methoxybenzamid [German] [ACD/IUPAC Name]
N-[1,3-Dimethyl-2-oxo-6-(1-pyrrolidinyl)-2,3-dihydro-1H-benzimidazol-5-yl]-2-methoxybenzamide [ACD/IUPAC Name]
N-[1,3-Diméthyl-2-oxo-6-(1-pyrrolidinyl)-2,3-dihydro-1H-benzimidazol-5-yl]-2-méthoxybenzamide [French] [ACD/IUPAC Name]
N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxy-benzamide
PF-05363047
PFI-4
[900305-37-5]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CCRIS 4693 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Safety:

      This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the PFI 4 probe summary on the SGC website. Tocris Bioscience 5576
    • Target Organs:

      BET bromodomain TargetMol T1973
    • Bio Activity:

      BET bromodomain MedChem Express HY-18664
      Bromodomains Tocris Bioscience 5576
      BRPF1 TargetMol T1973
      Cell Biology Tocris Bioscience 5576
      Cell Cycle/Checkpoint TargetMol T1973
      Cell Cycle/DNA Damage MedChem Express HY-18664
      Cell Cycle/DNA Damage; MedChem Express HY-18664
      Epigenetics Tocris Bioscience 5576
      PFI-4 is a potent and selective and cell permeable BRPF1 bromodomain inhibitor (IC50 = 80 nM). MedChem Express http://www.medchemexpress.com/SU9516.html, HY-18664
      Potent and selective BRPF1 bromodomain inhibitor Tocris Bioscience 5576
      Potent and selective BRPF1 bromodomain inhibitor (IC50 = 80 nM). Exhibits >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4. Disrupts BRPF1 bind ing to histone H3.3. Cell permeable. Tocris Bioscience 5576
      Potent and selective BRPF1 bromodomain inhibitor (IC50 = 80 nM). Exhibits >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4. Disrupts BRPF1 binding to histone H3.3. Cell permeable. Tocris Bioscience 5576

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.3±0.1 g/cm3
Boiling Point: 512.1±50.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.3 mmHg at 25°C
Enthalpy of Vaporization: 78.3±3.0 kJ/mol
Flash Point: 263.5±30.1 °C
Index of Refraction: 1.649
Molar Refractivity: 107.3±0.3 cm3
#H bond acceptors: 7
#H bond donors: 1
#Freely Rotating Bonds: 4
#Rule of 5 Violations: 0
ACD/LogP: 1.79
ACD/LogD (pH 5.5): 0.06
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 3.34
ACD/LogD (pH 7.4): 1.61
ACD/BCF (pH 7.4): 7.88
ACD/KOC (pH 7.4): 117.48
Polar Surface Area: 65 Å2
Polarizability: 42.6±0.5 10-24cm3
Surface Tension: 57.2±3.0 dyne/cm
Molar Volume: 294.5±3.0 cm3

Click to predict properties on the Chemicalize site






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