ChemSpider 2D Image | PCI-34051 | C17H16N2O3

PCI-34051

  • Molecular FormulaC17H16N2O3
  • Average mass296.320 Da
  • Monoisotopic mass296.116089 Da
  • ChemSpider ID22504677

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1H-Indole-6-carboxamide, N-hydroxy-1-[(4-methoxyphenyl)methyl]- [ACD/Index Name]
950762-95-5 [RN]
N-Hydroxy-1-(4-methoxybenzyl)-1H-indol-6-carboxamid [German] [ACD/IUPAC Name]
N-Hydroxy-1-(4-methoxybenzyl)-1H-indole-6-carboxamide [ACD/IUPAC Name]
N-Hydroxy-1-(4-méthoxybenzyl)-1H-indole-6-carboxamide [French] [ACD/IUPAC Name]
PCI-34051
PUI52VXV61
(S)-2-Amino-4-(butylthio)butanoic acid
1-(4-Methoxy-benzyl)-1H-indole-6-carboxylic acid hydroxyamide
1-(4-Methoxybenzyl)-N-hydroxy-1H-indole-6-carboxamide
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CCRIS 4693 [DBID]
PubChem Substance ID 329825761 [DBID]
  • References
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Biochemicals & small molecules/Antagonists & inhibitors Hello Bio [HB1393]
      Cell Cycle/DNA Damage MedChem Express HY-15224
      Cell Cycle/DNA Damage; MedChem Express HY-15224
      Deacetylases Tocris Bioscience 4643
      Enzymes Tocris Bioscience 4643
      Enzymes/Deacetylase/Histone deacetylase (HDAC) Hello Bio [HB1393]
      HDAC MedChem Express HY-15224
      Histone Deacetylases Tocris Bioscience 4643
      PCI-34051 is a specific inhibitor of HDAC8 with IC50 of 10 nM, with MedChem Express http://www.medchemexpress.com/ganetespib.html
      PCI-34051 is a specific inhibitor of HDAC8 with IC50 of 10 nM, with >200-fold selectivity over the other HDAC isoforms.; IC50 Value: 10 nM; Target: HDAC8; in vitro: PCI-34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias, but not in other hematopoietic or solid tumor lines. MedChem Express HY-15224
      PCI-34051 is a specific inhibitor of HDAC8 with IC50 of 10 nM, with >200-fold selectivity over the other HDAC isoforms.;IC50 Value: 10 nM;Target: HDAC8;In vitro: PCI-34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias, but not in other hematopoietic or solid tumor lines. Unlike broad-spectrum HDAC inhibitors, PCI-34051 does not cause detectable histone or tubulin acetylation. Cells defective in T-cell receptor signaling were still sensitive to PCI-34051-induced apoptosis, whereas a phospholipase C-gamma1 (PLCgamma1)-defective line was resistant. HDAC8-inhibitor specifically induces cell death in T-cell-derived lines, which is caspase dependent in vivo: MedChem Express HY-15224
      Potent and selective HDAC8 inhibitor Tocris Bioscience 4643
      Potent and selective histone deacetylase 8 (HDAC8) inhibitor (IC<sub>50</sub> = 10 nM). Shows >200-fold selectivity over other HDAC isoforms (IC<sub>50</sub> values are 2.9, 4, 13, >50 and >50 &micro;M for HDAC6, 1, 10, 2 and 3 respectively). Shows apoptotic and anti-cancer actions. Hello Bio [HB1393]
      Potent and selective histone deacetylase 8 (HDAC8) inhibitor (IC50 = 10 nM). Displays >200 fold selectivity over HDAC isoforms 1, 2, 3, 6 and 10. Induces apoptosis in cell lines derived from T cell ly mphomas or leukemias. Tocris Bioscience 4643
      Potent and selective histone deacetylase 8 (HDAC8) inhibitor (IC50 = 10 nM). Displays >200 fold selectivity over HDAC isoforms 1, 2, 3, 6 and 10. Induces apoptosis in cell lines derived from T cell lymphomas or leukemias. Tocris Bioscience 4643
      Potent, selective HDAC8 inhibitor Hello Bio [HB1393]

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.621
Molar Refractivity: 83.2±0.5 cm3
#H bond acceptors: 5
#H bond donors: 2
#Freely Rotating Bonds: 4
#Rule of 5 Violations: 0
ACD/LogP: 2.20
ACD/LogD (pH 5.5): 2.10
ACD/BCF (pH 5.5): 23.40
ACD/KOC (pH 5.5): 332.37
ACD/LogD (pH 7.4): 2.10
ACD/BCF (pH 7.4): 23.00
ACD/KOC (pH 7.4): 326.80
Polar Surface Area: 63 Å2
Polarizability: 33.0±0.5 10-24cm3
Surface Tension: 48.3±7.0 dyne/cm
Molar Volume: 236.4±7.0 cm3

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