ChemSpider 2D Image | SC66 | C18H16N2O

SC66

  • Molecular FormulaC18H16N2O
  • Average mass276.332 Da
  • Monoisotopic mass276.126251 Da
  • ChemSpider ID22940638

  • Double-bond stereo - Double-bond stereo

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(2E,6E)-2,6-Bis(4-pyridinylmethylen)cyclohexanon [German] [ACD/IUPAC Name]
(2E,6E)-2,6-Bis(4-pyridinylmethylene)cyclohexanone [ACD/IUPAC Name]
(2E,6E)-2,6-Bis(4-pyridinylmethylene)-cyclohexanone
(2E,6E)-2,6-Bis(4-pyridinylméthylène)cyclohexanone [French] [ACD/IUPAC Name]
871361-88-5 [RN]
Cyclohexanone, 2,6-bis(4-pyridinylmethylene)-, (2E,6E)- [ACD/Index Name]
MFCD05025493
SC66
SC-66
(2E,6E)-2,6-bis(4-pyridylmethylene)cyclohexanone
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CCRIS 4693 [DBID]
PubChem Substance ID 329825761 [DBID]
  • References
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Akt MedChem Express HY-19832
      Akt (PKB) inhibitor. Binds at an allosteric site. Interferes with PH domain-PIP3 binding and enhances Akt ubiquitination. Blocks mTORC1/2, decreases glucose uptake and cell viability. Shows anti-tumor actions. Hello Bio [HB1252]
      Akt (Protein Kinase B) Tocris Bioscience 4398
      Akt inhibitor Hello Bio [HB1252]
      Allosteric Akt inhibitor Tocris Bioscience 4398
      Allosteric inhibitor of Akt; interferes with pleckstrin homology domain binding to PIP3 and facilitates Akt ubiquitination. Exhibits anticancer activity in vitro and in vivo. Tocris Bioscience 4398
      Biochemicals & small molecules/Antagonists & inhibitors Hello Bio [HB1252]
      Enzymes Tocris Bioscience 4398
      Enzymes/Kinase/Akt / PKB Hello Bio [HB1252]
      Kinases Tocris Bioscience 4398
      PI3K/Akt/mTOR MedChem Express HY-19832
      PI3K/Akt/mTOR; MedChem Express HY-19832
      SC66 is a novel AKT inhibitor, IC50 values of approximately 0.75 ?g/ml at 72 hours in HepG2, HA22T/VGH and PLC/PRF/5 cells.; IC50 value: 0.75 ?g/ml (72 hours in HepG2, HA22T/VGH and PLC/PRF/5 cells) [1]; Target: Akt; in vitro: Each cell line had a different sensitivity to SC66, as evidenced by the IC50 values . MedChem Express HY-19832

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.2±0.1 g/cm3
Boiling Point: 514.5±50.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.3 mmHg at 25°C
Enthalpy of Vaporization: 78.6±3.0 kJ/mol
Flash Point: 260.0±36.5 °C
Index of Refraction: 1.683
Molar Refractivity: 85.3±0.3 cm3
#H bond acceptors: 3
#H bond donors: 0
#Freely Rotating Bonds: 2
#Rule of 5 Violations: 0
ACD/LogP: 3.03
ACD/LogD (pH 5.5): 2.80
ACD/BCF (pH 5.5): 75.62
ACD/KOC (pH 5.5): 729.78
ACD/LogD (pH 7.4): 2.88
ACD/BCF (pH 7.4): 90.99
ACD/KOC (pH 7.4): 878.12
Polar Surface Area: 43 Å2
Polarizability: 33.8±0.5 10-24cm3
Surface Tension: 62.5±3.0 dyne/cm
Molar Volume: 225.0±3.0 cm3

Click to predict properties on the Chemicalize site


Advertisement