ChemSpider 2D Image | AR-231453 | C21H24FN7O5S

AR-231453

  • Molecular FormulaC21H24FN7O5S
  • Average mass505.523 Da
  • Monoisotopic mass505.154358 Da
  • ChemSpider ID23330691

More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

733750-99-7 [RN]
AR-231453
N-[2-Fluor-4-(methylsulfonyl)phenyl]-6-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)-1-piperidinyl]-5-nitro-4-pyrimidinamin [German] [ACD/IUPAC Name]
N-[2-Fluoro-4-(methylsulfonyl)phenyl]-6-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)-1-piperidinyl]-5-nitro-4-pyrimidinamine [ACD/IUPAC Name]
N-[2-Fluoro-4-(méthylsulfonyl)phényl]-6-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)-1-pipéridinyl]-5-nitro-4-pyrimidinamine [French] [ACD/IUPAC Name]
(2-Fluoro-4-methanesulfonyl-phenyl)-{6-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-5-nitropyrimidin-4-yl}-amine
[733750-99-7]
4-pyrimidinamine, N-[2-fluoro-4-(methylsulfonyl)phenyl]-6-[4-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]-5-nitro- [ACD/Index Name]
AR 231453
AR 231453|AR-231,453|AR-231453
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

07Z1P4981I [DBID]
UNII:07Z1P4981I [DBID]
UNII-07Z1P4981I [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Safety:

      5 Axon Medchem 1572
      H303;H313;H317;H333;H334;H335;H373 Axon Medchem 1572
      IRRITANT Matrix Scientific 100507
      no pictogram Axon Medchem 1572
      P101;P102;P103;P260;P262;P263;P264;P270;P280;P304;P312;P340 Axon Medchem 1572
      Warning Axon Medchem 1572
    • Bio Activity:

      AR231453 is a potent and selective small molecule agonist of GPR119 that enhances glucose-dependent insulin secretion and glucagon-like peptide 1 (GLP-1) release; Antidiabetic agent. MedChem Express
      AR231453 is a potent and selective small molecule agonist of GPR119 that enhances glucose-dependent insulin secretion and glucagon-like peptide 1 (GLP-1) release; Antidiabetic agent.; IC50 value: ; Target: GPR119; in vitro: The GPR119-specific agonist AR231453 significantly increased cAMP accumulation and insulin release in both HIT-T15 cells and rodent islets. MedChem Express HY-15564
      AR231453 is a potent and selective small molecule agonist of GPR119 that enhances glucose-dependent insulin secretion and glucagon-like peptide 1 (GLP-1) release; Antidiabetic agent.;IC50 value: ;Target: GPR119;In vitro: The GPR119-specific agonist AR231453 significantly increased cAMP accumulation and insulin release in both HIT-T15 cells and rodent islets. In both cases, loss of GPR119 rendered AR231453 inactive [1]. In GLUTag cells, a well-established model of intestinal L-cell function, the potent GPR119 agonist AR231453 stimulated cAMP accumulation and GLP-1 release [2].;In vivo: AR231453 also enhanced glucose-dependent insulin release in vivo and improved oral glucose tolerance in wild-type mice but not in GPR119-deficient mice. Diabetic KK/A(y) mice were also highly responsive to AR231453. Orally active GPR119 agonists may offer significant promise as novel antihyperglycemic agents acting in a glucose-dependent fashion [1]. When administered in mice, AR231453 increased acti MedChem Express HY-15564
      GPCR/G protein MedChem Express HY-15564
      GPCR/G protein; MedChem Express HY-15564
      GPR119 MedChem Express HY-15564

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.4±0.1 g/cm3
Boiling Point: 703.9±70.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.2 mmHg at 25°C
Enthalpy of Vaporization: 103.0±3.0 kJ/mol
Flash Point: 379.5±35.7 °C
Index of Refraction: 1.602
Molar Refractivity: 121.9±0.4 cm3
#H bond acceptors: 12
#H bond donors: 1
#Freely Rotating Bonds: 7
#Rule of 5 Violations: 3
ACD/LogP: 5.35
ACD/LogD (pH 5.5): 4.35
ACD/BCF (pH 5.5): 1196.62
ACD/KOC (pH 5.5): 5545.88
ACD/LogD (pH 7.4): 4.36
ACD/BCF (pH 7.4): 1204.59
ACD/KOC (pH 7.4): 5582.83
Polar Surface Area: 168 Å2
Polarizability: 48.3±0.5 10-24cm3
Surface Tension: 64.9±3.0 dyne/cm
Molar Volume: 355.5±3.0 cm3

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