ChemSpider 2D Image | UCPH 101 | C27H22N2O3

UCPH 101

  • Molecular FormulaC27H22N2O3
  • Average mass422.475 Da
  • Monoisotopic mass422.163055 Da
  • ChemSpider ID23334447

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1118460-77-7 [RN]
2-Amino-4-(4-methoxyphenyl)-7-(1-naphthyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromen-3-carbonitril [German] [ACD/IUPAC Name]
2-Amino-4-(4-methoxyphenyl)-7-(1-naphthyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile [ACD/IUPAC Name]
2-Amino-4-(4-méthoxyphényl)-7-(1-naphtyl)-5-oxo-5,6,7,8-tétrahydro-4H-chromène-3-carbonitrile [French] [ACD/IUPAC Name]
2-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4,6,7,8-tetrahydrochromene-3-carbonitrile
2-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile
4H-1-Benzopyran-3-carbonitrile, 2-amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(1-naphthalenyl)-5-oxo- [ACD/Index Name]
UCPH 101
UCPH-101
(R)-(+)-WIN 55212 |
More...
  • References
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      <p>UCPH-101 is a potent, selective, non-competitive inhibitor of the EAAT1 (Excitatory Amino Acid Transporter 1) glutamate transporter (IC<sub>50</sub> = 660 nM). UCPH-101 shows &gt;400-fold selectivity for EAAT1 over EAAT2 and EAAT3 and shows no inhibitory activity at EAAT4 and EAAT5 in a patch-clamp electrophysiology assay (in which final concentration was up to 10 &mu;M). <a href="/ucph-102.html" title="UCPH-102 | BBB permeable EAAT1 inhibitor | Hello Bio" target="_self">UCPH-102</a> which is blood brain barrier permeable is now also available.</p> Hello Bio HB0630
      <p>UCPH-101 is a potent, selective, non-competitive inhibitor of the EAAT1 (Excitatory Amino Acid Transporter 1) glutamate transporter (IC<sub>50</sub> = 660 nM). UCPH-101 shows &gt;400-fold selectivity for EAAT1 over EAAT2 and EAAT3 and shows no inhibitory activity at EAAT4 and EAAT5 in a patch-clamp electrophysiology assay (in which final concentration was up to 10 &mu;M). <a href=/ucph-102.html title=UCPH-102 | BBB permeable EAAT1 inhibitor | Hello Bio target=_self>UCPH-102</a> which is blood brain barrier permeable is now also available.</p> Hello Bio HB0630
      Biochemicals & small molecules/Antagonists & inhibitors Hello Bio HB0630
      Glutamate Transporters Tocris Bioscience 3490
      Neurotransmitter Transporters Tocris Bioscience 3490
      Receptors & Transporters/Transporters/Glutamate uptake & transport Hello Bio HB0630
      Selective non-substrate EAAT1 inhibitor Tocris Bioscience 3490
      Selective non-substrate inhibitor of EAAT1 (IC50 values are 660, >300000 and >300000 nM for EAAT1, EAAT2 and EAAT3 respectively). Also demonstrates no significant inhibition at EAAT4 or EAAT5 in a pat ch-clamp electrophysiology assay (at final concentration up to 10 ?M). Tocris Bioscience 3490
      Selective non-substrate inhibitor of EAAT1 (IC50 values are 660, >300000 and >300000 nM for EAAT1, EAAT2 and EAAT3 respectively). Also demonstrates no significant inhibition at EAAT4 or EAAT5 in a patch-clamp electrophysiology assay (at final concentration up to 10 ?M). Tocris Bioscience 3490
      Selective non-substrate inhibitor of EAAT1 (IC50 values are 660, >300000 and >300000 nM for EAAT1, EAAT2 and EAAT3 respectively). Also demonstrates no significant inhibition at EAAT4 or EAAT5 in a patch-clamp electrophysiology assay (at final concentration up to 10 muM). Tocris Bioscience 3490
      Transporters Tocris Bioscience 3490
      UCPH-101 is a potent, selective, non-competitive EAAT1 inhibitor Hello Bio HB0630

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point: 703.5±60.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.2 mmHg at 25°C
Enthalpy of Vaporization: 102.9±3.0 kJ/mol
Flash Point: 379.3±32.9 °C
Index of Refraction: 1.692
Molar Refractivity: 121.9±0.4 cm3
#H bond acceptors: 5
#H bond donors: 2
#Freely Rotating Bonds: 4
#Rule of 5 Violations: 0
ACD/LogP: 4.16
ACD/LogD (pH 5.5): 4.19
ACD/BCF (pH 5.5): 898.59
ACD/KOC (pH 5.5): 4519.73
ACD/LogD (pH 7.4): 4.19
ACD/BCF (pH 7.4): 903.26
ACD/KOC (pH 7.4): 4543.22
Polar Surface Area: 85 Å2
Polarizability: 48.3±0.5 10-24cm3
Surface Tension: 65.1±5.0 dyne/cm
Molar Volume: 318.1±5.0 cm3

Click to predict properties on the Chemicalize site


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