ChemSpider 2D Image | Olesoxime | C27H45NO

Olesoxime

  • Molecular FormulaC27H45NO
  • Average mass399.652 Da
  • Monoisotopic mass399.350128 Da
  • ChemSpider ID23350363
  • defined stereocentres - 7 of 7 defined stereocentres


More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

22033-87-0 [RN]
Cholest-4-en-3-one, oxime [ACD/Index Name]
N-Hydroxycholest-4-en-3-imin [German] [ACD/IUPAC Name]
N-Hydroxycholest-4-en-3-imine [ACD/IUPAC Name]
N-Hydroxycholest-4-én-3-imine [French] [ACD/IUPAC Name]
olesoxima [Spanish] [INN]
olésoxime [French] [INN]
olesoximum [Latin] [INN]
Cholest-4-en-3-one oxime
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

TRO 19622 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Bio Activity:

      Binds voltage-dependent anion channel (VDAC) Tocris Bioscience 2906
      Ion Channels Tocris Bioscience 2906
      Neuroprotective and neuroregenerative compound. Rescues motor neurons from axotomy-induced cell death and promotes nerve regeneration following sciatic nerve crush in vivo. Binds directly to two compo nents of the mitochondrial permeability pore, the voltage-dependent anion channel (VDAC) and translocator protein; thought to inhibit MPTP opening. Tocris Bioscience 2906
      Neuroprotective and neuroregenerative compound. Rescues motor neurons from axotomy-induced cell death and promotes nerve regeneration following sciatic nerve crush in vivo. Binds directly to two components of the mitochondrial permeability pore, the voltage-dependent anion channel (VDAC) and translocator protein; thought to inhibit MPTP opening. Tocris Bioscience 2906
      Other Channel Modulators Tocris Bioscience 2906
      Others MedChem Express HY-14796
      TRO19622, a small cholesterol-like molecule, is a neuroregenerative and neuroprotective compound.; IC50 Value: 3.2 ? 0.2 ?M(EC50) [1]; Target: Others; in vitro: TRO19622 maintained survival of 74 ? 10 % (n = 8) of the neurons supported by a cocktail of trophic factors (1 ng/ml brain-derived neurotrophic factor, 1 ng/ml glia-derived neurotrophic factor, and 10 ng/ml ciliary neurotrophic factor), def ined as 100%. MedChem Express HY-14796

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.1±0.1 g/cm3
Boiling Point: 510.0±23.0 °C at 760 mmHg
Vapour Pressure: 0.0±3.0 mmHg at 25°C
Enthalpy of Vaporization: 89.9±6.0 kJ/mol
Flash Point: 341.0±11.9 °C
Index of Refraction: 1.583
Molar Refractivity: 120.8±0.5 cm3
#H bond acceptors: 2
#H bond donors: 1
#Freely Rotating Bonds: 5
#Rule of 5 Violations: 1
ACD/LogP: 9.85
ACD/LogD (pH 5.5): 8.58
ACD/BCF (pH 5.5): 1000000.00
ACD/KOC (pH 5.5): 1103995.50
ACD/LogD (pH 7.4): 8.58
ACD/BCF (pH 7.4): 1000000.00
ACD/KOC (pH 7.4): 1103864.63
Polar Surface Area: 33 Å2
Polarizability: 47.9±0.5 10-24cm3
Surface Tension: 37.7±7.0 dyne/cm
Molar Volume: 361.3±7.0 cm3

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