ChemSpider 2D Image | Nesiritide | C143H244N50O42S4

Nesiritide

  • Molecular FormulaC143H244N50O42S4
  • Average mass3464.037 Da
  • Monoisotopic mass3461.737793 Da
  • ChemSpider ID24603113
  • defined stereocentres - 28 of 28 defined stereocentres


More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

Nesiritida [Spanish] [INN]
Nesiritide [INN] [Wiki]
Nésiritide [French] [INN]
Nesiritidum [Latin] [INN]
[124584-08-3]
114471-18-0 [RN]
124584-08-3 [RN]
bnp-32
BNP-32 (human)
BRAIN NATRIURETIC PEPTIDE (1-32)
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  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Bio Activity:

      Endogenous peptide agonist at ANP receptor A (NPR1) Tocris Bioscience 3522
      Endogenous peptide secreted from cardiac ventricles in response to volume increase and pressure overload that acts as an agonist at atrial natriuretic peptide (ANP) receptor A (NRP1). Decreases de nov o collagen synthesis and increases MMP gene expression in vitro. Exhibits natriuretic, vasodilatory and lusitropic activity and inhibits the sympathetic and renin-angiotensin-aldosterone systems in vi vo. Tocris Bioscience 3522
      Endogenous peptide secreted from cardiac ventricles in response to volume increase and pressure overload that acts as an agonist at atrial natriuretic peptide (ANP) receptor A (NRP1). Decreases de novo collagen synthesis and increases MMP gene expression in vitro. Exhibits natriuretic, vasodilatory and lusitropic activity and inhibits the sympathetic and renin-angiotensin-aldosterone systems in vivo. Tocris Bioscience 3522
      Enzyme-Linked Receptors Tocris Bioscience 3522
      Natriuretic Peptide Receptor Tocris Bioscience 3522

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.5±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.679
Molar Refractivity: 855.1±0.5 cm3
#H bond acceptors: 92
#H bond donors: 65
#Freely Rotating Bonds: 91
#Rule of 5 Violations: 3
ACD/LogP: -16.34
ACD/LogD (pH 5.5):
ACD/BCF (pH 5.5):
ACD/KOC (pH 5.5):
ACD/LogD (pH 7.4):
ACD/BCF (pH 7.4):
ACD/KOC (pH 7.4):
Polar Surface Area: 1614 Å2
Polarizability: 339.0±0.5 10-24cm3
Surface Tension: 69.5±7.0 dyne/cm
Molar Volume: 2265.8±7.0 cm3

Click to predict properties on the Chemicalize site





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