ChemSpider 2D Image | APR-246 | C10H17NO3

APR-246

  • Molecular FormulaC10H17NO3
  • Average mass199.247 Da
  • Monoisotopic mass199.120850 Da
  • ChemSpider ID24606048

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1-Azabicyclo[2.2.2]octan-3-one, 2-(hydroxymethyl)-2-(methoxymethyl)- [ACD/Index Name]
2-(Hydroxymethyl)-2-(methoxymethyl)chinuclidin-3-on [German] [ACD/IUPAC Name]
2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one [ACD/IUPAC Name]
2-(Hydroxyméthyl)-2-(méthoxyméthyl)quinuclidin-3-one [French] [ACD/IUPAC Name]
5291-32-7 [RN]
APR-246
PRIMA-1MET
UNII:Z41TGB4080
Z41TGB4080
[5291-32-7]
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Cell Biology Tocris Bioscience 3710
      Cell Cycle Tocris Bioscience 3710
      Methylated derivative of PRIMA-1 (Cat. No. 1862). Restores mutant activity p53 activity. Acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation. Tocris Bioscience 3710
      p53 Tocris Bioscience 3710
      Restores mutant p53 activity Tocris Bioscience 3710

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.2±0.1 g/cm3
Boiling Point: 313.8±17.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.5 mmHg at 25°C
Enthalpy of Vaporization: 64.3±6.0 kJ/mol
Flash Point: 143.6±20.9 °C
Index of Refraction: 1.537
Molar Refractivity: 51.5±0.4 cm3
#H bond acceptors: 4
#H bond donors: 1
#Freely Rotating Bonds: 3
#Rule of 5 Violations: 0
ACD/LogP: 0.61
ACD/LogD (pH 5.5): -0.02
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 18.34
ACD/LogD (pH 7.4): 0.20
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 30.32
Polar Surface Area: 50 Å2
Polarizability: 20.4±0.5 10-24cm3
Surface Tension: 48.1±5.0 dyne/cm
Molar Volume: 165.0±5.0 cm3

Click to predict properties on the Chemicalize site


Advertisement