ChemSpider 2D Image | Foretinib | C34H34F2N4O6

Foretinib

  • Molecular FormulaC34H34F2N4O6
  • Average mass632.654 Da
  • Monoisotopic mass632.244629 Da
  • ChemSpider ID24608641

More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1,1-Cyclopropanedicarboxamide, N-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N'-(4-fluorophenyl)- [ACD/Index Name]
81FH7VK1C4
849217-64-7 [RN]
9202
EXEL-2880
N-[3-Fluor-4-({6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-chinolinyl}oxy)phenyl]-N'-(4-fluorphenyl)-1,1-cyclopropandicarboxamid [German] [ACD/IUPAC Name]
N-[3-Fluoro-4-({6-méthoxy-7-[3-(4-morpholinyl)propoxy]-4-quinoléinyl}oxy)phényl]-N'-(4-fluorophényl)-1,1-cyclopropanedicarboxamide [French] [ACD/IUPAC Name]
N-[3-Fluoro-4-({6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl}oxy)phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide [ACD/IUPAC Name]
[849217-64-7]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

GSK089 [DBID]
GSK1363089 [DBID]
GSK1363089G [DBID]
XL880 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Safety:

      5 Axon Medchem 1582
      H303;H313;H317;H333;H334;H335;H373 Axon Medchem 1582
      no pictogram Axon Medchem 1582
      P101;P102;P103;P260;P262;P263;P264;P270;P280;P304;P312;P340 Axon Medchem 1582
      Warning Axon Medchem 1582
    • Bio Activity:

      c-Met/HGFR MedChem Express HY-10338
      c-Met/HGFR VEGFR MedChem Express HY-10338
      Enzyme-Linked Receptors Tocris Bioscience 6056
      Foretinib (GSK1363089; XL880; EXEL-2880; GSK089) is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met and KDR with IC50 of 0.4 nM and 0.9 nM. MedChem Express HY-10338
      MET Receptors Tocris Bioscience 6056
      Potent inhibitor of MET, VEGFR2, Ron and AXL Tocris Bioscience 6056
      Potent inhibitor of MET, VEGFR2, Ron and AXL (IC50 values are 0.4, 0.9, 3 and 11 nM, respectively). Also potently inhibits Tie-2, Flt-1, Flt-3, Flt-4, KIT, PDGFR? and PDGFR?. Inhibits migration and invasion of B16F10 melanoma cells in vitro. Suppresses B16F10 tumor growth and metastasis in mice. Orally available. Tocris Bioscience 6056
      Potent inhibitor of MET, VEGFR2, Ron and AXL (IC50 values are 0.4, 0.9, 3 and 11 nM, respectively). Also potently inhibits Tie-2, Flt-1, Flt-3, Flt-4, KIT, PDGFRalpha and PDGFRbeta. Inhibits migration and invasion of B16F10 melanoma cells in vitro. Suppresses B16F10 tumor growth and metastasis in mice. Orally available. Tocris Bioscience 6056
      Protein Tyrosine Kinase/RTK MedChem Express HY-10338
      Protein Tyrosine Kinase/RTK; MedChem Express HY-10338
      Receptor Tyrosine Kinases (RTKs) Tocris Bioscience 6056

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.4±0.1 g/cm3
Boiling Point: 828.5±65.0 °C at 760 mmHg
Vapour Pressure: 0.0±3.0 mmHg at 25°C
Enthalpy of Vaporization: 120.4±3.0 kJ/mol
Flash Point: 454.8±34.3 °C
Index of Refraction: 1.649
Molar Refractivity: 167.9±0.3 cm3
#H bond acceptors: 10
#H bond donors: 2
#Freely Rotating Bonds: 12
#Rule of 5 Violations: 3
ACD/LogP: 5.12
ACD/LogD (pH 5.5): 2.42
ACD/BCF (pH 5.5): 15.94
ACD/KOC (pH 5.5): 82.58
ACD/LogD (pH 7.4): 3.98
ACD/BCF (pH 7.4): 568.07
ACD/KOC (pH 7.4): 2943.09
Polar Surface Area: 111 Å2
Polarizability: 66.5±0.5 10-24cm3
Surface Tension: 62.2±3.0 dyne/cm
Molar Volume: 460.8±3.0 cm3

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