ChemSpider 2D Image | BIX01294 | C28H38N6O2


  • Molecular FormulaC28H38N6O2
  • Average mass490.640 Da
  • Monoisotopic mass490.305634 Da
  • ChemSpider ID24634766

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

935693-62-2 [RN]
BIX 01294
N-(1-Benzyl-4-piperidinyl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-4-chinazolinamin [German] [ACD/IUPAC Name]
N-(1-Benzyl-4-piperidinyl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-4-quinazolinamine [ACD/IUPAC Name]
N-(1-Benzyl-4-pipéridinyl)-6,7-diméthoxy-2-(4-méthyl-1,4-diazépan-1-yl)-4-quinazolinamine [French] [ACD/IUPAC Name]
[935693-62-2] [RN]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Bio Activity:

      BIX01294 is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 ?M.; IC50 Value: 2.7 ?M; Target: HMTase; BIX-01294, a diazepin-quinazolinamine derivative, is a selective inhibitor of G9a histone methyl transferase (G9a HMTase) that impairs G9a HMTase and generation of H3K9me2 in vitro. MedChem Express HY-10587
      Cell Cycle/DNA Damage MedChem Express HY-10587
      Cell Cycle/DNA Damage; MedChem Express HY-10587
      HMTase MedChem Express HY-10587

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.2±0.1 g/cm3
Boiling Point: 654.6±65.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.0 mmHg at 25°C
Enthalpy of Vaporization: 96.4±3.0 kJ/mol
Flash Point: 349.7±34.3 °C
Index of Refraction: 1.627
Molar Refractivity: 145.5±0.3 cm3
#H bond acceptors: 8
#H bond donors: 1
#Freely Rotating Bonds: 7
#Rule of 5 Violations: 0
ACD/LogP: 2.81
ACD/LogD (pH 5.5): -1.69
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.00
ACD/LogD (pH 7.4): 0.64
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 3.25
Polar Surface Area: 66 Å2
Polarizability: 57.7±0.5 10-24cm3
Surface Tension: 54.7±3.0 dyne/cm
Molar Volume: 410.4±3.0 cm3

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