ChemSpider 2D Image | JZL195 | C24H23N3O5


  • Molecular FormulaC24H23N3O5
  • Average mass433.457 Da
  • Monoisotopic mass433.163757 Da
  • ChemSpider ID24655100

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1-Piperazinecarboxylic acid, 4-[(3-phenoxyphenyl)methyl]-, 4-nitrophenyl ester [ACD/Index Name]
4-(3-Phénoxybenzyl)-1-pipérazinecarboxylate de 4-nitrophényle [French] [ACD/IUPAC Name]
4-Nitrophenyl 4-(3-phenoxybenzyl)-1-piperazinecarboxylate [ACD/IUPAC Name]
4-Nitrophenyl-4-(3-phenoxybenzyl)-1-piperazincarboxylat [German] [ACD/IUPAC Name]
JZL195 [Wiki]
(4-nitrophenyl) 4-[(3-phenoxyphenyl)methyl]piperazine-1-carboxylate
1210004-12-8 [RN]
4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate
JZL 195
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Target Organs:

      FAAH inhibitor TargetMol T2338
    • Bio Activity:

      Dual FAAH and MAGL inhibitor Tocris Bioscience 4715
      Dual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) (IC50 values are 2 and 4 nM respectively). Elevates anandamide and 2-arachidonoylglycerol levels in vivo. Shown t o impair short-term memory in mice. Tocris Bioscience 4715
      FAAH MedChem Express HY-15250
      FAAH/MAGL TargetMol T2338
      JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor with IC50 of 13 nM and 19 nM for mouse brain FAAH and MAGL respectively. MedChem Express
      JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor with IC50 of 13 nM and 19 nM for mouse brain FAAH and MAGL respectively.; IC50 value: 13 nM/19 nM (mouse brain FAAH/MAGL) [1]; Target: dual FAAH/MAGL inhibitor; in vitro: JZL195 shows only modest and incomplete inhibitory activity against NTE (IC50 >5 uM). MedChem Express HY-15250
      Metabolism TargetMol T2338
      Metabolism/Protease MedChem Express HY-15250

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.3±0.1 g/cm3
Boiling Point: 581.8±50.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.6 mmHg at 25°C
Enthalpy of Vaporization: 87.0±3.0 kJ/mol
Flash Point: 305.7±30.1 °C
Index of Refraction: 1.632
Molar Refractivity: 118.6±0.3 cm3
#H bond acceptors: 8
#H bond donors: 0
#Freely Rotating Bonds: 7
#Rule of 5 Violations: 1
ACD/LogP: 5.63
ACD/LogD (pH 5.5): 3.78
ACD/BCF (pH 5.5): 294.42
ACD/KOC (pH 5.5): 1269.40
ACD/LogD (pH 7.4): 4.48
ACD/BCF (pH 7.4): 1473.78
ACD/KOC (pH 7.4): 6354.31
Polar Surface Area: 88 Å2
Polarizability: 47.0±0.5 10-24cm3
Surface Tension: 57.6±3.0 dyne/cm
Molar Volume: 332.4±3.0 cm3

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