ChemSpider 2D Image | JZL195 | C24H23N3O5

JZL195

  • Molecular FormulaC24H23N3O5
  • Average mass433.457 Da
  • Monoisotopic mass433.163757 Da
  • ChemSpider ID24655100

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1210004-12-8 [RN]
1-Piperazinecarboxylic acid, 4-[(3-phenoxyphenyl)methyl]-, 4-nitrophenyl ester [ACD/Index Name]
4-(3-Phénoxybenzyl)-1-pipérazinecarboxylate de 4-nitrophényle [French] [ACD/IUPAC Name]
4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 4-nitrophenyl ester
4-Nitrophenyl 4-(3-phenoxybenzyl)-1-piperazinecarboxylate [ACD/IUPAC Name]
4-Nitrophenyl-4-(3-phenoxybenzyl)-1-piperazincarboxylat [German] [ACD/IUPAC Name]
JZL 195
JZL195 [Wiki]
MFCD18382122
(4-nitrophenyl) 4-[(3-phenoxyphenyl)methyl]piperazine-1-carboxylate
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CCRIS 4693 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      FAAH inhibitor TargetMol T2338

    • Bio Activity:

      Dual FAAH and MAGL inhibitor Tocris Bioscience 4715
      Dual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) (IC50 values are 2 and 4 nM respectively). Elevates anandamide and 2-arachidonoylglycerol levels in vivo. Shown t o impair short-term memory in mice. Tocris Bioscience 4715
      Dual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) (IC50 values are 2 and 4 nM respectively). Elevates anandamide and 2-arachidonoylglycerol levels in vivo. Shown to impair short-term memory in mice. Tocris Bioscience 4715
      Enzymes Tocris Bioscience 4715
      FAAH MedChem Express HY-15250
      FAAH MAGL MedChem Express HY-15250
      FAAH/MAGL TargetMol T2338
      Fatty Acid Amide Hydrolase (FAAH) Tocris Bioscience 4715
      Hydrolases Tocris Bioscience 4715
      JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor with IC50 of 13 nM and 19 nM for mouse brain FAAH and MAGL respectively. MedChem Express
      JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor with IC50 of 13 nM and 19 nM for mouse brain FAAH and MAGL respectively.; IC50 value: 13 nM/19 nM (mouse brain FAAH/MAGL) [1]; Target: dual FAAH/MAGL inhibitor; in vitro: JZL195 shows only modest and incomplete inhibitory activity against NTE (IC50 >5 uM). MedChem Express HY-15250
      JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor with IC50 of 13 nM and 19 nM for mouse brain FAAH and MAGL respectively.;IC50 value: 13 nM/19 nM (mouse brain FAAH/MAGL) [1];Target: dual FAAH/MAGL inhibitor;In vitro: JZL195 shows only modest and incomplete inhibitory activity against NTE (IC50 >5 uM). At higher concentrations, JZL195 inhibited ABHD6 but not any of the other brain serine hydrolases detected in our competitive ABPP assays. JZL195 also inhibited rat and human FAAH and MAGL enzymes with IC50 values in the range of 10?100 nM based on competitive ABPP assays [1].;In vivo: A time course analysis of mice given one administration ofJZL195 (20 mg/kg, i.p.) revealed that blockade of FAAH andMAGL lasted at least 10 h as judged by gel-based ABPP or AEAand 2-AG hydrolysis assays [1]. The effect of systemic injections of a range of doses of JZL195 and the pan-cannabinoid receptor agonist WIN55212 were performed 1 day following intraplantar injection of CFA in MedChem Express HY-15250
      Metabolism TargetMol T2338
      Metabolism/Protease MedChem Express HY-15250
      Metabolism/Protease; MedChem Express HY-15250

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.3±0.1 g/cm3
Boiling Point: 581.8±50.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.6 mmHg at 25°C
Enthalpy of Vaporization: 87.0±3.0 kJ/mol
Flash Point: 305.7±30.1 °C
Index of Refraction: 1.632
Molar Refractivity: 118.6±0.3 cm3
#H bond acceptors: 8
#H bond donors: 0
#Freely Rotating Bonds: 7
#Rule of 5 Violations: 1
ACD/LogP: 5.63
ACD/LogD (pH 5.5): 3.78
ACD/BCF (pH 5.5): 294.42
ACD/KOC (pH 5.5): 1269.40
ACD/LogD (pH 7.4): 4.48
ACD/BCF (pH 7.4): 1473.78
ACD/KOC (pH 7.4): 6354.31
Polar Surface Area: 88 Å2
Polarizability: 47.0±0.5 10-24cm3
Surface Tension: 57.6±3.0 dyne/cm
Molar Volume: 332.4±3.0 cm3

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