ChemSpider 2D Image | BIX02189 | C27H28N4O2

BIX02189

  • Molecular FormulaC27H28N4O2
  • Average mass440.537 Da
  • Monoisotopic mass440.221222 Da
  • ChemSpider ID24747391

  • Double-bond stereo - Double-bond stereo

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(3Z)-3-[({3-[(Dimethylamino)methyl]phenyl}amino)(phenyl)methylen]-N,N-dimethyl-2-oxo-6-indolincarboxamid [German] [ACD/IUPAC Name]
(3Z)-3-[({3-[(Dimethylamino)methyl]phenyl}amino)(phenyl)methylene]-N,N-dimethyl-2-oxo-6-indolinecarboxamide [ACD/IUPAC Name]
(3Z)-3-[({3-[(Diméthylamino)méthyl]phényl}amino)(phényl)méthylène]-N,N-diméthyl-2-oxo-6-indolinecarboxamide [French] [ACD/IUPAC Name]
(3Z)-3-[({3-[(dimethylamino)methyl]phenyl}amino)(phenyl)methylidene]-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide
(3Z)-3-[({3-[(dimethylamino)methyl]phenyl}amino)(phenyl)methylidene]-N,N-dimethyl-2-oxo-2,3-dihydro-1H-indole-6-carboxamide
1094614-85-3 [RN]
1265916-41-3 [RN]
1H-Indole-6-carboxamide, 3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-, (3Z)- [ACD/Index Name]
3-[[3-[(dimethylamino)methyl]anilino]-phenylmethylidene]-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide
BIX02189
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CCRIS 4693 [DBID]
PubChem Substance ID 329825761 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      MEK inhibitor TargetMol T2416

    • Bio Activity:

      BIX02189 is a selective MEK5/ERK5 inhibitor with an IC50 of 59 nM. MedChem Express http://www.medchemexpress.com/bix02189.html, HY-12056
      Enzymes Tocris Bioscience 4842
      Kinases Tocris Bioscience 4842
      MAPK MedChem Express HY-12056
      MAPK ; MedChem Express HY-12056
      MAPK Signaling TargetMol T2416
      MEK Tocris Bioscience 4842
      MEK MedChem Express HY-12056
      MEK5/ERK5/TGF??/MEK1/ERK1/JNK1/EGFR/STK16 TargetMol T2416
      Selective MEK5 and ERK5 inhibitor Tocris Bioscience 4842
      Selective MEK5 and ERK5 inhibitor (IC50 values are 1.5 and 59 nM respectively). Inhibits sorbitol-induced ERK5 phosphorylation in HeLa cells. Selective for MEK5 and ERK5 over MEK1/2, ERK1/2 and a pane l of 87 kinases. Induces apoptosis in acute myeloid leukemia tumor cells. Tocris Bioscience 4842
      Selective MEK5 and ERK5 inhibitor (IC50 values are 1.5 and 59 nM respectively). Inhibits sorbitol-induced ERK5 phosphorylation in HeLa cells. Selective for MEK5 and ERK5 over MEK1/2, ERK1/2 and a panel of 87 kinases. Induces apoptosis in acute myeloid leukemia tumor cells. Tocris Bioscience 4842

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.2±0.1 g/cm3
Boiling Point: 653.4±55.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.0 mmHg at 25°C
Enthalpy of Vaporization: 96.3±3.0 kJ/mol
Flash Point: 349.0±31.5 °C
Index of Refraction: 1.659
Molar Refractivity: 132.0±0.3 cm3
#H bond acceptors: 6
#H bond donors: 2
#Freely Rotating Bonds: 6
#Rule of 5 Violations: 0
ACD/LogP: 2.05
ACD/LogD (pH 5.5): 0.23
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.50
ACD/LogD (pH 7.4): 1.68
ACD/BCF (pH 7.4): 5.05
ACD/KOC (pH 7.4): 43.04
Polar Surface Area: 65 Å2
Polarizability: 52.3±0.5 10-24cm3
Surface Tension: 55.5±3.0 dyne/cm
Molar Volume: 357.9±3.0 cm3

Click to predict properties on the Chemicalize site


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