ChemSpider 2D Image | Capmatinib | C23H17FN6O

Capmatinib

  • Molecular FormulaC23H17FN6O
  • Average mass412.419 Da
  • Monoisotopic mass412.144775 Da
  • ChemSpider ID25069712

More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1029712-80-8 [RN]
18352802 [Beilstein]
2-Fluoro-N-méthyl-4-[7-(6-quinoléinylméthyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide [French] [ACD/IUPAC Name]
2-Fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide
2-Fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide [ACD/IUPAC Name]
2-fluoro-N-methyl-4-{7-[(quinolin-6-yl)methyl]imidazo[1,2- b][1,2,4]triazin-2-yl}benzamide
4-[7-(6-Chinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]-2-fluor-N-methylbenzamid [German] [ACD/IUPAC Name]
9948
Benzamide, 2-fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]- [ACD/Index Name]
capmatinib [French] [INN]
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

TY34L4F9OZ [DBID]
CCRIS 4693 [DBID]
INC280 [DBID]
INC-280 [DBID]
INC28060 [DBID]
INCB 28060 [DBID]
INCB-028060 [DBID]
INCB28060 [DBID]
INCB-28060 [DBID]
UNII:TY34L4F9OZ [DBID]
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  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Appearance:

      Not Available Novochemy [NC-43060]
    • Safety:

      20/21/22 Novochemy [NC-43060]
      20/21/36/37/39 Novochemy [NC-43060]
      GHS07; GHS09 Novochemy [NC-43060]
      H332; H403 Novochemy [NC-43060]
      P102; P210; P262; P270; P302+P352; P308+P313 Novochemy [NC-43060]
      R52/1645 Novochemy [NC-43060]
      Warning Novochemy [NC-43060]
    • Target Organs:

      c-Met inhibitor TargetMol T1963
    • Bio Activity:

      c-Met TargetMol T1963
      c-Met/HGFR MedChem Express HY-13404
      INCB28060 is a novel orally active inhibitor (IC50=0.13 nM) of c-MET kinase. MedChem Express
      INCB28060 is a novel orally active inhibitor (IC50=0.13 nM) of c-MET kinase.; IC50 Value: 0.13?0.05 nM(recombinant human wild-type c-MET) [1]; Target: c-Met; INCB28060 potently and specifically inhibits c-MET enzyme activity, c-MET-mediated signal transduction, and the c-MET-dependent neoplastic phenotype of tumor cells . MedChem Express HY-13404
      INCB28060 is a novel orally active inhibitor (IC50=0.13 nM) of c-MET kinase.;IC50 Value: 0.13?0.05 nM(recombinant human wild-type c-MET) [1];Target: c-Met;INCB28060 potently and specifically inhibits c-MET enzyme activity, c-MET-mediated signal transduction, and the c-MET-dependent neoplastic phenotype of tumor cells . ;In vitro: INCB28060 exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10,000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines [1].;In vivo: Oral dosing of INCB28060 results in time- and dose-dependent inhibition of c-MET phosphorylation and tumor growth in c-MET-driven mouse tumor models, and the inhibitor is well tolerated at doses that achieve complete tumor inhibition [1]. Activated c-MET positively regulates the activity of epidermal growth factor receptors (EGFR) and HER-3, as well as e MedChem Express HY-13404
      Protein Tyrosine Kinase/RTK MedChem Express HY-13404
      Protein Tyrosine Kinase/RTK; MedChem Express HY-13404
      Tyrosine Kinase/Adaptors TargetMol T1963

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.4±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.717
Molar Refractivity: 115.6±0.5 cm3
#H bond acceptors: 7
#H bond donors: 1
#Freely Rotating Bonds: 4
#Rule of 5 Violations: 0
ACD/LogP: -0.12
ACD/LogD (pH 5.5): 1.63
ACD/BCF (pH 5.5): 9.60
ACD/KOC (pH 5.5): 164.85
ACD/LogD (pH 7.4): 1.72
ACD/BCF (pH 7.4): 11.96
ACD/KOC (pH 7.4): 205.44
Polar Surface Area: 85 Å2
Polarizability: 45.8±0.5 10-24cm3
Surface Tension: 55.0±7.0 dyne/cm
Molar Volume: 293.6±7.0 cm3

Click to predict properties on the Chemicalize site






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