ChemSpider 2D Image | Rapastinel | C18H31N5O6

Rapastinel

  • Molecular FormulaC18H31N5O6
  • Average mass413.469 Da
  • Monoisotopic mass413.227448 Da
  • ChemSpider ID25069944

  • defined stereocentres - 6 of 6 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(2S,3R)-2-{[(2S)-1-[(2S)-1-[(2S,3R)-2-amino-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]pyrrolidin-2-yl]formamido}-3-hydroxybutanamide
117928-94-6 [RN]
L-Threoninamide, L-threonyl-L-prolyl-L-prolyl- [ACD/Index Name]
L-Threonyl-L-prolyl-L-prolyl-L-threoninamid [German] [ACD/IUPAC Name]
L-Threonyl-L-prolyl-L-prolyl-L-threoninamide [ACD/IUPAC Name]
L-Thréonyl-L-prolyl-L-prolyl-L-thréoninamide [French] [ACD/IUPAC Name]
rapastinel [French] [INN]
rapastinel [Spanish] [INN]
Rapastinel [INN] [USAN] [Wiki]
rapastinelum [Latin] [INN]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

6A1X56B95E [DBID]
9981 [DBID]
GLYX 13 [DBID]
GLYX-13 [DBID]
UNII:6A1X56B95E [DBID]
UNII-6A1X56B95E [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Dopamine Receptor NMDA Receptor MedChem Express HY-16728
      Glutamate (Ionotropic) Receptors Tocris Bioscience 3406
      GPCR/G protein; Membrane Transporter/Ion Channel; Neuronal Signaling; MedChem Express HY-16728
      Ion Channels Tocris Bioscience 3406
      Ligand-gated Ion Channels Tocris Bioscience 3406
      NMDA receptor partial agonist that acts at the glycine site. Simultaneously acts as a promoter of the induction of long-term potentiation (LTP) and as a suppressor of long-term depression (LTD). Exhib its nootropic, neuroprotective and antinociceptive activity, and enhances learning, memory and cognition in vivo. Brain penetrant. Tocris Bioscience 3406
      NMDA receptor partial agonist that acts at the glycine site. Simultaneously acts as a promoter of the induction of long-term potentiation (LTP) and as a suppressor of long-term depression (LTD). Exhibits nootropic, neuroprotective and antinociceptive activity, and enhances learning, memory and cognition in vivo. Brain penetrant. Tocris Bioscience 3406
      NMDA receptor partial agonist; acts at the glycine site Tocris Bioscience 3406
      Rapastinel (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator that has characteristics of a glycine site partial agonist. ;Target: NMDARapastinel is a robust cognitive enhancer and facilitates hippocampal long-term potentiation (LTP) of synaptic transmission in slices. MedChem Express HY-16728

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.4±0.1 g/cm3
Boiling Point: 844.2±65.0 °C at 760 mmHg
Vapour Pressure: 0.0±0.6 mmHg at 25°C
Enthalpy of Vaporization: 139.5±6.0 kJ/mol
Flash Point: 464.4±34.3 °C
Index of Refraction: 1.590
Molar Refractivity: 101.8±0.3 cm3
#H bond acceptors: 11
#H bond donors: 7
#Freely Rotating Bonds: 7
#Rule of 5 Violations: 2
ACD/LogP: -2.02
ACD/LogD (pH 5.5): -3.90
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.00
ACD/LogD (pH 7.4): -2.43
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 1.00
Polar Surface Area: 179 Å2
Polarizability: 40.3±0.5 10-24cm3
Surface Tension: 70.7±3.0 dyne/cm
Molar Volume: 301.7±3.0 cm3

Click to predict properties on the Chemicalize site


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