ChemSpider 2D Image | PF-3845 | C24H23F3N4O2

PF-3845

  • Molecular FormulaC24H23F3N4O2
  • Average mass456.460 Da
  • Monoisotopic mass456.177307 Da
  • ChemSpider ID26232165

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1196109-52-0 [RN]
1-Piperidinecarboxamide, N-3-pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]- [ACD/Index Name]
N-(3-Pyridinyl)-4-(3-{[5-(trifluormethyl)-2-pyridinyl]oxy}benzyl)-1-piperidincarboxamid [German] [ACD/IUPAC Name]
N-(3-Pyridinyl)-4-(3-{[5-(trifluoromethyl)-2-pyridinyl]oxy}benzyl)-1-piperidinecarboxamide [ACD/IUPAC Name]
N-(3-Pyridinyl)-4-(3-{[5-(trifluorométhyl)-2-pyridinyl]oxy}benzyl)-1-pipéridinecarboxamide [French] [ACD/IUPAC Name]
N-(pyridin-3-yl)-4-[(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)methyl]piperidine-1-carboxamide
N-3-Pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-1-piperidinecarboxamide
PF-3845 [Wiki]
Q3PW846TYN
[1196109-52-0] [RN]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

PubChem Substance ID 329825761 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Safety:

      Sold for research purposes under agreement from Pfizer Inc. Tocris Bioscience 4175

    • Bio Activity:

      Enzymes Tocris Bioscience 4175
      FAAH MedChem Express HY-14380
      Fatty Acid Amide Hydrolase (FAAH) Tocris Bioscience 4175
      Hydrolases Tocris Bioscience 4175
      Neuronal Signaling MedChem Express HY-14380
      Neuronal Signaling; MedChem Express HY-14380
      PF-3845 is a selective fatty acid amide hydrolase (FAAH) inhibitor (Ki = 0.23 ?M); showing negligible activity against FAAH2.; IC50 value: 0.23 uM; Target: FAAH; PF-3845 selectively inhibits FAAH by carbamylating FAAH's serine nucleophile [1]. MedChem Express HY-14380
      Selective FAAH inhibitor Tocris Bioscience 4175
      Selective fatty acid amide hydrolase (FAAH) inhibitor (Ki = 0.23 ?M). Reduces inflammatory pain via a cannabinoid receptor-dependent mechanism. Highly efficacious and selective in vivo. Displays no ac tivity at FAAH-2 (IC50 >10 ?M). Tocris Bioscience 4175
      Selective fatty acid amide hydrolase (FAAH) inhibitor (Ki = 0.23 ?M). Reduces inflammatory pain via a cannabinoid receptor-dependent mechanism. Highly efficacious and selective in vivo. Displays no activity at FAAH-2 (IC50 >10 ?M). Tocris Bioscience 4175
      Selective fatty acid amide hydrolase (FAAH) inhibitor (Ki = 0.23 muM). Reduces inflammatory pain via a cannabinoid receptor-dependent mechanism. Highly efficacious and selective in vivo. Displays no activity at FAAH-2 (IC50 >10 muM). Tocris Bioscience 4175

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point: 623.6±55.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.8 mmHg at 25°C
Enthalpy of Vaporization: 92.4±3.0 kJ/mol
Flash Point: 330.9±31.5 °C
Index of Refraction: 1.595
Molar Refractivity: 117.2±0.3 cm3
#H bond acceptors: 6
#H bond donors: 1
#Freely Rotating Bonds: 6
#Rule of 5 Violations: 0
ACD/LogP: 3.72
ACD/LogD (pH 5.5): 3.68
ACD/BCF (pH 5.5): 317.66
ACD/KOC (pH 5.5): 1818.28
ACD/LogD (pH 7.4): 3.93
ACD/BCF (pH 7.4): 567.39
ACD/KOC (pH 7.4): 3247.73
Polar Surface Area: 67 Å2
Polarizability: 46.4±0.5 10-24cm3
Surface Tension: 53.2±3.0 dyne/cm
Molar Volume: 345.0±3.0 cm3

Click to predict properties on the Chemicalize site


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