ChemSpider 2D Image | imeglimin | C6H13N5

imeglimin

  • Molecular FormulaC6H13N5
  • Average mass155.201 Da
  • Monoisotopic mass155.117096 Da
  • ChemSpider ID26232690

  • defined stereocentres - 1 of 1 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(+)-(6R)-1,6-dihydro-N,N,6-triméthyl-1,3,5-triazine-2,4-diamine hypoglycémiant [French]
(4R)-6-(dimethylamino)-4-methyl-4,5-dihydro-1,3,5-triazin-2-amine hypoglycaemic
(4R)-6-(dimetilamino)-4-metil-4,5-dihidro-1,3,5-triazin-2-amina hipoglucemiante [Spanish]
(6R)-N,N,6-Trimethyl-3,6-dihydro-1,3,5-triazin-2,4-diamin [German] [ACD/IUPAC Name]
(6R)-N,N,6-Trimethyl-3,6-dihydro-1,3,5-triazine-2,4-diamine [ACD/IUPAC Name]
(6R)-N,N,6-Triméthyl-3,6-dihydro-1,3,5-triazine-2,4-diamine [French] [ACD/IUPAC Name]
(6S)-N2,N2,6-Trimethyl-1,6-dihydro-1,3,5-triazin-2,4-diamin [German] [ACD/IUPAC Name]
(6S)-N2,N2,6-Trimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine [ACD/IUPAC Name]
(6S)-N2,N2,6-Triméthyl-1,6-dihydro-1,3,5-triazine-2,4-diamine [French] [ACD/IUPAC Name]
1,3,5-Triazine-2,4-diamine, 1,6-dihydro-N2,N2,6-trimethyl-, (6S)- [ACD/Index Name]
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

8969 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      AMPK MedChem Express HY-14771
      Imeglimin(EMD-387008) is the first in a new tetrahydrotriazine-containing class of oral antidiabetic agents, the glimins; It has been shown to act on the liver, muscle and pancreatic ?-cells to uniquely target the key defects of type 2 diabetes.; IC50 Value: ; Target: AMPK stimulator; in vitro: ; in vivo: A total of 156 patients were randomized 1:1 to receive imeglimin (1,500 mg twice a day) or placebo added to a stable dose of metformin (1,500-2,000 mg/day). MedChem Express HY-14771
      PI3K/Akt/mTOR MedChem Express HY-14771
      PI3K/Akt/mTOR; MedChem Express HY-14771

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.3±0.1 g/cm3
Boiling Point: 239.9±23.0 °C at 760 mmHg
Vapour Pressure: 0.0±0.5 mmHg at 25°C
Enthalpy of Vaporization: 47.7±3.0 kJ/mol
Flash Point: 98.9±22.6 °C
Index of Refraction: 1.622
Molar Refractivity: 42.1±0.5 cm3
#H bond acceptors: 5
#H bond donors: 3
#Freely Rotating Bonds: 1
#Rule of 5 Violations: 0
ACD/LogP: -1.39
ACD/LogD (pH 5.5): -2.93
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.00
ACD/LogD (pH 7.4): -2.91
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 1.00
Polar Surface Area: 66 Å2
Polarizability: 16.7±0.5 10-24cm3
Surface Tension: 44.7±7.0 dyne/cm
Molar Volume: 119.6±7.0 cm3

Click to predict properties on the Chemicalize site


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