ChemSpider 2D Image | LY2608204 | C28H37N3O3S3

LY2608204

  • Molecular FormulaC28H37N3O3S3
  • Average mass559.807 Da
  • Monoisotopic mass559.199707 Da
  • ChemSpider ID26323625

  • defined stereocentres - 2 of 2 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(1R,2S)-2-cyclohexyl-1-[4-(cyclopropanesulfonyl)phenyl]-N-(5-{[2-(pyrrolidin-1-yl)ethyl]sulfanyl}-1,3-thiazol-2-yl)cyclopropane-1-carboxamide
(1R,2S)-2-Cyclohexyl-1-[4-(cyclopropylsulfonyl)phenyl]-N-(5-{[2-(1-pyrrolidinyl)ethyl]sulfanyl}-1,3-thiazol-2-yl)cyclopropancarboxamid [German] [ACD/IUPAC Name]
(1R,2S)-2-Cyclohexyl-1-[4-(cyclopropylsulfonyl)phenyl]-N-(5-{[2-(1-pyrrolidinyl)ethyl]sulfanyl}-1,3-thiazol-2-yl)cyclopropanecarboxamide [ACD/IUPAC Name]
(1R,2S)-2-Cyclohexyl-1-[4-(cyclopropylsulfonyl)phényl]-N-(5-{[2-(1-pyrrolidinyl)éthyl]sulfanyl}-1,3-thiazol-2-yl)cyclopropanecarboxamide [French] [ACD/IUPAC Name]
1234703-40-2 [RN]
Cyclopropanecarboxamide, 2-cyclohexyl-1-[4-(cyclopropylsulfonyl)phenyl]-N-[5-[[2-(1-pyrrolidinyl)ethyl]thio]-2-thiazolyl]-, (1R,2S)- [ACD/Index Name]
LY2608204
LY-2608204
(1R,2S)-2-cyclohexyl-1-(4-(cyclopropylsulfonyl)phenyl)-N-(5-((2-(pyrrolidin-1-yl)ethyl)thio)thiazol-2-yl)cyclopropane-1-carboxamide
(1R,2S)-2-Cyclohexyl-1-(4-(cyclopropylsulfonyl)phenyl)-N-(5-((2-(pyrrolidin-1-yl)ethyl)thio)thiazol-2-yl)cyclopropanecarboxamide
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

5A0L003HEY [DBID]
UNII:5A0L003HEY [DBID]
UNII-5A0L003HEY [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Glucokinase MedChem Express HY-13529
      LY2608204 is a activator of glucokinase (GK) with EC50 of 42 nM. MedChem Express
      LY2608204 is a activator of glucokinase (GK) with EC50 of 42 nM.; IC 50 value: 42 nM (EC50); Target: glucokinase; in vitro: LY2608204 activates glucokinase (GK) with EC50 of 42 nM at 10 mM glucose with a concentration dependent manner at lower glucose concentrations. MedChem Express HY-13529
      LY2608204 is a activator of glucokinase (GK) with EC50 of 42 nM.;IC 50 value: 42 nM (EC50);Target: glucokinase;In vitro: LY2608204 activates glucokinase (GK) with EC50 of 42 nM at 10 mM glucose with a concentration dependent manner at lower glucose concentrations. LY2608204 also stimulates glucose metabolism in rat insulinoma INS1-E cells with EC50 of 579 nM.;In vivo: LY2608204 decreases plasma glucose in a dose-dependent manner at both fasted and postprandial glucose levels. A maximal lowering of glucose AUC versus the untreated control group is observed with the high dose (30 mg/kg) and represents a 42% decrease. Interpolation of the data show that a 20% glucose AUC decrease occurs at an average LY2608204 concentration of 99 ng/mL (179 nM) in plasma, corresponding to a 6.9 mg/kg LY2608204 dose. The in vivo blood brain barrier permeability of LY2608204 results in a mean brain/plasma ratio of 0.17 five minutes post-dose with a mean total brain level of 0.539 nmol/g.Clinical tra MedChem Express HY-13529
      Metabolism/Protease MedChem Express HY-13529
      Metabolism/Protease; MedChem Express HY-13529

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.4±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.658
Molar Refractivity: 151.6±0.4 cm3
#H bond acceptors: 6
#H bond donors: 1
#Freely Rotating Bonds: 10
#Rule of 5 Violations: 1
ACD/LogP: 4.97
ACD/LogD (pH 5.5): 1.93
ACD/BCF (pH 5.5): 3.23
ACD/KOC (pH 5.5): 10.94
ACD/LogD (pH 7.4): 2.85
ACD/BCF (pH 7.4): 26.57
ACD/KOC (pH 7.4): 90.09
Polar Surface Area: 141 Å2
Polarizability: 60.1±0.5 10-24cm3
Surface Tension: 67.4±5.0 dyne/cm
Molar Volume: 411.7±5.0 cm3

Click to predict properties on the Chemicalize site


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