ChemSpider 2D Image | bpr1j-097 | C27H28N6O3S

bpr1j-097

  • Molecular FormulaC27H28N6O3S
  • Average mass516.615 Da
  • Monoisotopic mass516.194336 Da
  • ChemSpider ID26617198

More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1327167-19-0 [RN]
4-(4-Methyl-1-piperazinyl)-N-(3-{3-[(phenylsulfonyl)amino]phenyl}-1H-pyrazol-5-yl)benzamid [German] [ACD/IUPAC Name]
4-(4-Methyl-1-piperazinyl)-N-(3-{3-[(phenylsulfonyl)amino]phenyl}-1H-pyrazol-5-yl)benzamide [ACD/IUPAC Name]
4-(4-Méthyl-1-pipérazinyl)-N-(3-{3-[(phénylsulfonyl)amino]phényl}-1H-pyrazol-5-yl)benzamide [French] [ACD/IUPAC Name]
Benzamide, 4-(4-methyl-1-piperazinyl)-N-[3-[3-[(phenylsulfonyl)amino]phenyl]-1H-pyrazol-5-yl]- [ACD/Index Name]
bpr1j-097
(2-cyanophenyl) 2-pentylcyclohexanecarboxylate
4-(4-methyl-1-piperazinyl)-N-[5-[3-[(phenylsulfonyl)amino]phenyl]-1H-pyrazol-3-yl]-benzamide
4-(4-Methylpiperazin-1-yl)-N-(5-(3-(phenylsulfonamido)phenyl)-1H-pyrazol-3-yl)benzamide
http:////www.amadischem.com/proen/493769/
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Target Organs:

      FLT3 inhibitor TargetMol T2272
    • Bio Activity:

      BPR1J-097 is a novel small molecule FLT-3 inhibitor(IC50=11?7 nM) with promising in vivo anti-tumour activities; inhibits FLT-3 D835Y with an IC50 of 3 nM. MedChem Express HY-13537
      BPR1J-097 is a novel small molecule FLT-3 inhibitor(IC50=11?7 nM) with promising in vivo anti-tumour activities; inhibits FLT-3 D835Y with an IC50 of 3 nM. ;IC50 value: 11?7 nM(Flt3);3 nM (FLT-3 D835Y) [1];Target: Flt3 inhibitor;The 50% inhibitory concentration (IC50) of BPR1J-097 required to inhibit FLT3 kinase activity ranged from 1 to 10 nM, and the 50% growth inhibition concentrations (GC50s) were 21?7 and 46?14 nM for MOLM-13 and MV4-11 cells, respectively. BPR1J-097 inhibited FLT3/signal transducer and activator of transcription 5 phosphorylation and triggered apoptosis in FLT3-driven AML cells. BPR1J-097 also showed favourable pharmacokinetic property and pronounced dose-dependent tumour growth inhibition and regression in FLT3-driven AML murine xenograft models. MedChem Express HY-13537
      BPR1J-097 is a novel small molecule FLT-3 inhibitor(IC50=11±7 nM) with promising in vivo anti-tumour activities; inhibits FLT-3 D835Y with an IC50 of 3 nM. MedChem Express http://www.medchemexpress.com/BPR1J-097.html
      FLT3 MedChem Express HY-13537
      FLT3 TargetMol T2272
      Protein Tyrosine Kinase/RTK MedChem Express HY-13537
      Protein Tyrosine Kinase/RTK; MedChem Express HY-13537
      Tyrosine Kinase/Adaptors TargetMol T2272

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.4±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.678
Molar Refractivity: 142.3±0.4 cm3
#H bond acceptors: 9
#H bond donors: 3
#Freely Rotating Bonds: 7
#Rule of 5 Violations: 1
ACD/LogP: 3.24
ACD/LogD (pH 5.5): 0.91
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 8.36
ACD/LogD (pH 7.4): 2.46
ACD/BCF (pH 7.4): 32.37
ACD/KOC (pH 7.4): 294.43
Polar Surface Area: 119 Å2
Polarizability: 56.4±0.5 10-24cm3
Surface Tension: 67.3±3.0 dyne/cm
Molar Volume: 377.6±3.0 cm3

Click to predict properties on the Chemicalize site






Advertisement