ChemSpider 2D Image | LY2874455 | C21H19Cl2N5O2

LY2874455

  • Molecular FormulaC21H19Cl2N5O2
  • Average mass444.314 Da
  • Monoisotopic mass443.091583 Da
  • ChemSpider ID28189058
  • Double-bond stereo - Double-bond stereo

    defined stereocentres - 1 of 1 defined stereocentres


More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1254473-64-7 [RN]
1H-Pyrazole-1-ethanol, 4-[(E)-2-[5-[(1R)-1-(3,5-dichloro-4-pyridinyl)ethoxy]-1H-indazol-3-yl]ethenyl]- [ACD/Index Name]
2-{4-[(1E)-2-{5-[(1R)-1-(3,5-dichloropyridin-4-yl)ethoxy]-1H-indazol-3-yl}ethenyl]-1H-pyrazol-1-yl}ethan-1-ol
2-{4-[(1E)-2-{5-[(1R)-1-(3,5-dichloropyridin-4-yl)ethoxy]-1H-indazol-3-yl}ethenyl]pyrazol-1-yl}ethanol
2-{4-[(E)-2-{5-[(1R)-1-(3,5-Dichlor-4-pyridinyl)ethoxy]-1H-indazol-3-yl}vinyl]-1H-pyrazol-1-yl}ethanol [German] [ACD/IUPAC Name]
2-{4-[(E)-2-{5-[(1R)-1-(3,5-Dichloro-4-pyridinyl)ethoxy]-1H-indazol-3-yl}vinyl]-1H-pyrazol-1-yl}ethanol [ACD/IUPAC Name]
2-{4-[(E)-2-{5-[(1R)-1-(3,5-Dichloro-4-pyridinyl)éthoxy]-1H-indazol-3-yl}vinyl]-1H-pyrazol-1-yl}éthanol [French] [ACD/IUPAC Name]
LY2874455
LY-2874455
(-)-LY 2874455
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

E9M363811V [DBID]
UNII:E9M363811V [DBID]
UNII-E9M363811V [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Bio Activity:

      FGFR MedChem Express HY-13304
      LY2874455 is a novel and potent FGF/FGFR inhibitor. MedChem Express http://www.medchemexpress.com/sr-3677.html, HY-13304
      LY2874455 is a novel and potent FGF/FGFR inhibitor. ;IC50 value:;Target: FGFRLY2874455 exhibits a potent activity against FGF/FGFR-mediated signaling in several cancer cell lines and shows an excellent broad spectrum of antitumor activity in several tumor xenograft models representing the major FGF/FGFR relevant tumor histologies including lung, gastric, and bladder cancers and multiple myeloma, and with a well-defined pharmacokinetic/pharmacodynamic relationship. MedChem Express HY-13304
      Protein Tyrosine Kinase/RTK MedChem Express HY-13304
      Protein Tyrosine Kinase/RTK; MedChem Express HY-13304

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.4±0.1 g/cm3
Boiling Point: 672.6±55.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.2 mmHg at 25°C
Enthalpy of Vaporization: 103.8±3.0 kJ/mol
Flash Point: 360.5±31.5 °C
Index of Refraction: 1.683
Molar Refractivity: 116.6±0.5 cm3
#H bond acceptors: 7
#H bond donors: 2
#Freely Rotating Bonds: 7
#Rule of 5 Violations: 0
ACD/LogP: 3.88
ACD/LogD (pH 5.5): 3.82
ACD/BCF (pH 5.5): 468.02
ACD/KOC (pH 5.5): 2837.73
ACD/LogD (pH 7.4): 3.82
ACD/BCF (pH 7.4): 468.04
ACD/KOC (pH 7.4): 2837.87
Polar Surface Area: 89 Å2
Polarizability: 46.2±0.5 10-24cm3
Surface Tension: 54.1±7.0 dyne/cm
Molar Volume: 307.5±7.0 cm3

Click to predict properties on the Chemicalize site






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