ChemSpider 2D Image | Lucitanib | C26H25N3O4

Lucitanib

  • Molecular FormulaC26H25N3O4
  • Average mass443.494 Da
  • Monoisotopic mass443.184509 Da
  • ChemSpider ID28189586

More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1058137-23-7 [RN]
1-Naphthalenecarboxamide, 6-[[7-[(1-aminocyclopropyl)methoxy]-6-methoxy-4-quinolinyl]oxy]-N-methyl- [ACD/Index Name]
6-({7-[(1-Aminocyclopropyl)methoxy]-6-methoxy-4-chinolinyl}oxy)-N-methyl-1-naphthamid [German] [ACD/IUPAC Name]
6-({7-[(1-Aminocyclopropyl)méthoxy]-6-méthoxy-4-quinoléinyl}oxy)-N-méthyl-1-naphtamide [French] [ACD/IUPAC Name]
6-({7-[(1-Aminocyclopropyl)methoxy]-6-methoxy-4-quinolinyl}oxy)-N-methyl-1-naphthamide [ACD/IUPAC Name]
9581
CO-3810
E3810
Lucitanib [INN]
Lucitanib [Spanish] [INN] [USAN]
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

E-3810 [DBID]
E 3810 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Chemical Class:

      A naphthalenecarboxamide obtained from formal condensation of the carboxy group of aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl}oxy)-1-naphthoic acid with methylamine. ChEBI CHEBI:65209
    • Bio Activity:

      E-3810 is a novel dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs) with antiangiogenic activity. MedChem Express http://www.medchemexpress.com/alk-inhibitor-1.html, HY-15391
      E-3810 is a novel dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs) with antiangiogenic activity. ;IC50 value:;Target: VEGFR/FGFRVEGFR/FGFR dual kinase inhibitor E-3810 inhibits VEGFR-1, -2, -3 and FGFR-1, -2 kinases in the nM range, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Both VEGFRs and FGFRs belong to the family of receptor tyrosine kinases that may be upregulated in various tumor cell types. MedChem Express HY-15391
      FGFR MedChem Express HY-15391
      FGFR VEGFR MedChem Express HY-15391
      Protein Tyrosine Kinase/RTK MedChem Express HY-15391
      Protein Tyrosine Kinase/RTK; MedChem Express HY-15391

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.3±0.1 g/cm3
Boiling Point: 696.5±50.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.2 mmHg at 25°C
Enthalpy of Vaporization: 102.0±3.0 kJ/mol
Flash Point: 375.0±30.1 °C
Index of Refraction: 1.669
Molar Refractivity: 128.8±0.3 cm3
#H bond acceptors: 7
#H bond donors: 3
#Freely Rotating Bonds: 7
#Rule of 5 Violations: 0
ACD/LogP: 3.81
ACD/LogD (pH 5.5): 0.30
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 2.03
ACD/LogD (pH 7.4): 2.48
ACD/BCF (pH 7.4): 33.92
ACD/KOC (pH 7.4): 309.45
Polar Surface Area: 96 Å2
Polarizability: 51.0±0.5 10-24cm3
Surface Tension: 58.3±3.0 dyne/cm
Molar Volume: 345.1±3.0 cm3

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