ChemSpider 2D Image | regorafenib hydrate | C21H17ClF4N4O4

regorafenib hydrate

  • Molecular FormulaC21H17ClF4N4O4
  • Average mass500.831 Da
  • Monoisotopic mass500.087433 Da
  • ChemSpider ID28295228

More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1019206-88-2 [RN]
2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-, hydrate (1:1) [ACD/Index Name]
4-[4-({[4-Chlor-3-(trifluormethyl)phenyl]carbamoyl}amino)-3-fluorphenoxy]-N-methyl-2-pyridincarboxamidhydrat (1:1) [German] [ACD/IUPAC Name]
4-[4-({[4-chloro-3-(trifluoromethyl) phenyl] carbamoyl} amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide monohydrate
4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide hydrate (1:1) [ACD/IUPAC Name]
4-[4-({[4-Chloro-3-(trifluorométhyl)phényl]carbamoyl}amino)-3-fluorophénoxy]-N-méthyl-2-pyridinecarboxamide, hydrate (1:1) [French] [ACD/IUPAC Name]
4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide monohydrate
bay 73-4506 monohydrate
regorafenib hydrate [INN] [USAN]
regorafenib monohydrate
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

MGN125FS9D [DBID]
UNII:MGN125FS9D [DBID]
UNII-MGN125FS9D [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Chemical Class:

      A hydrate that is the monohydrate form of anhydrous regorafenib. Used for for the treatment of metastatic colorectal cancer in patients who have previously received chemotherapy, anti-EGFR or anti-VEG F therapy. ChEBI CHEBI:68646
    • Bio Activity:

      Protein Tyrosine Kinase/RTK MedChem Express HY-10331A
      Protein Tyrosine Kinase/RTK; MedChem Express HY-10331A
      Regorafenib (BAY 73-4506) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFR?, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively.; IC50 value:; Target: VEGFR; Raf; PDGFR?; in vitro: Regorafenib strongly prevents VEGFR2 autophosphorylation in NIH-3T3/VEGFR2 cells with IC50 of 3 nM. MedChem Express HY-10331A
      VEGFR MedChem Express HY-10331A

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

No predicted properties have been calculated for this compound.

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