ChemSpider 2D Image | ML277 | C23H25N3O4S2

ML277

  • Molecular FormulaC23H25N3O4S2
  • Average mass471.592 Da
  • Monoisotopic mass471.128632 Da
  • ChemSpider ID28520478
  • defined stereocentres - 1 of 1 defined stereocentres


More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(2R)-N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1-[(4-methylphenyl)sulfonyl]-2-piperidincarboxamid [German] [ACD/IUPAC Name]
(2R)-N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1-[(4-methylphenyl)sulfonyl]-2-piperidinecarboxamide [ACD/IUPAC Name]
(2R)-N-[4-(4-Méthoxyphényl)-1,3-thiazol-2-yl]-1-[(4-méthylphényl)sulfonyl]-2-pipéridinecarboxamide [French] [ACD/IUPAC Name]
2-Piperidinecarboxamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-, (2R)- [ACD/Index Name]
ML277
(2R)?-N-?[4-?(4-?methoxyphenyl)?-?2-?thiazolyl]?-?1-?[(4-?methylphenyl)?sulfonyl]?-2-?piperidinecarboxamid?e
(2R)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylphenyl)sulfonylpiperidine-2-carboxamide
(2R)-N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-2-piperidinecarboxamide
(R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide
[1401242-74-7]
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CCRIS 4693 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Bio Activity:

      Ion Channels Tocris Bioscience 4777
      Membrane Tranporter/Ion Channel MedChem Express HY-12343
      Membrane Tranporter/Ion Channel; MedChem Express HY-12343
      ML277(CID53347902) is a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator with EC50 of 270 nM. MedChem Express
      ML277(CID53347902) is a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator with EC50 of 270 nM.; IC50 value: 270 nM (EC50) [1]; Target: K(v)7.1 activator; ML277 was shown to be highly selective against other KCNQ channels (>100-fold selectivity versus KCNQ2 and KCNQ4) as well as against the distantly related hERG potassium channel.; MedChem Express HY-12343
      ML277(CID53347902) is a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator with EC50 of 270 nM.;IC50 value: 270 nM (EC50) [1];Target: K(v)7.1 activatorML277 was shown to be highly selective against other KCNQ channels (>100-fold selectivity versus KCNQ2 and KCNQ4) as well as against the distantly related hERG potassium channel. MedChem Express HY-12343
      Potassium Channel MedChem Express HY-12343
      Potassium Channels Tocris Bioscience 4777
      Selective Kv7.1 (KCNQ1) potassium channel activator (EC50 = 260 nM). Exhibits >100-fold selectivity versus KCNQ2, KCNQ4 and hERG potassium channels. Augments IKs current of cultured human cardiomyocyt es and shortens action potential duration. Tocris Bioscience 4777
      Selective Kv7.1 (KCNQ1) potassium channel activator (EC50 = 260 nM). Exhibits >100-fold selectivity versus KCNQ2, KCNQ4 and hERG potassium channels. Augments IKs current of cultured human cardiomyocytes and shortens action potential duration. Tocris Bioscience 4777
      Selective Kv7.1 (KCNQ1) potassium channel activator; augments IKs current Tocris Bioscience 4777
      Voltage-Gated Potassium Channels Tocris Bioscience 4777

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.3±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.631
Molar Refractivity: 125.3±0.4 cm3
#H bond acceptors: 7
#H bond donors: 1
#Freely Rotating Bonds: 6
#Rule of 5 Violations: 0
ACD/LogP: 4.68
ACD/LogD (pH 5.5): 4.17
ACD/BCF (pH 5.5): 875.76
ACD/KOC (pH 5.5): 4441.32
ACD/LogD (pH 7.4): 4.13
ACD/BCF (pH 7.4): 793.34
ACD/KOC (pH 7.4): 4023.36
Polar Surface Area: 125 Å2
Polarizability: 49.7±0.5 10-24cm3
Surface Tension: 59.1±3.0 dyne/cm
Molar Volume: 351.6±3.0 cm3

Click to predict properties on the Chemicalize site






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