ChemSpider 2D Image | MPI-0479605 | C22H29N7O

MPI-0479605

  • Molecular FormulaC22H29N7O
  • Average mass407.512 Da
  • Monoisotopic mass407.243347 Da
  • ChemSpider ID28529203

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1246529-32-7 [RN]
9H-Purine-2,6-diamine, N6-cyclohexyl-N2-[2-methyl-4-(4-morpholinyl)phenyl]- [ACD/Index Name]
MPI-0479605
N6-Cyclohexyl-N2-[2-methyl-4-(4-morpholinyl)phenyl]-3H-purin-2,6-diamin [German] [ACD/IUPAC Name]
N6-Cyclohexyl-N2-[2-methyl-4-(4-morpholinyl)phenyl]-3H-purine-2,6-diamine [ACD/IUPAC Name]
N6-Cyclohexyl-N2-[2-méthyl-4-(4-morpholinyl)phényl]-3H-purine-2,6-diamine [French] [ACD/IUPAC Name]
N6-Cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2,6-diamine
N6-cyclohexyl-N2-[2-methyl-4-(morpholin-4-yl)phenyl]-7H-purine-2,6-diamine
[1246529-32-7] [RN]
6-N-cyclohexyl-2-N-(2-methyl-4-morpholin-4-ylphenyl)-7H-purine-2,6-diamine
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      Kinesin inhibitor TargetMol T2313

    • Bio Activity:

      Cell Cycle/Checkpoint TargetMol T2313
      Cell Cycle/DNA Damage MedChem Express HY-12660
      Cell Cycle/DNA Damage; MedChem Express HY-12660
      Kinesin MedChem Express HY-12660
      Kinesin Mps1 MedChem Express HY-12660
      MPI-0479605 is a potent, ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, MedChem Express http://www.medchemexpress.com/Glutaminase-C-IN-1.html
      MPI-0479605 is a potent, ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, > 40-fold selectivity over other kinases.; IC50 value: 1.8 nM; Target: Mps 1 ; in vitro: MPI-0479605 impairs the SAC and the bipolar attachment of chromosomes to the mitotic spindle, which results in chromosome segregation defects and aneuploidy. MedChem Express HY-12660
      MPI-0479605 is a potent, ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, > 40-fold selectivity over other kinases.;IC50 value: 1.8 nM;Target: Mps 1 ;In vitro: MPI-0479605 impairs the SAC and the bipolar attachment of chromosomes to the mitotic spindle, which results in chromosome segregation defects and aneuploidy. MPI-0479605 results in a significant decrease in cell viability with GI50 ranging from 30 to 100 nM in a panel of tumor cell lines. In addition, MPI-0479605 also causes cell growth arrest and ultimately promotes cell death by apoptosis or mitotic catastrophe. ;In vivo: MPI-0479605 (30 mg/kg daily or 150 mg/kg every 4 days, i.p.) exhibits antitumor activity in colon cancer xenograft models. MedChem Express HY-12660
      Mps1 TargetMol T2313

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.700
Molar Refractivity: 119.5±0.3 cm3
#H bond acceptors: 8
#H bond donors: 3
#Freely Rotating Bonds: 5
#Rule of 5 Violations: 0
ACD/LogP: 1.69
ACD/LogD (pH 5.5): 2.82
ACD/BCF (pH 5.5): 63.29
ACD/KOC (pH 5.5): 498.86
ACD/LogD (pH 7.4): 3.28
ACD/BCF (pH 7.4): 181.35
ACD/KOC (pH 7.4): 1429.46
Polar Surface Area: 91 Å2
Polarizability: 47.4±0.5 10-24cm3
Surface Tension: 74.4±3.0 dyne/cm
Molar Volume: 309.1±3.0 cm3

Click to predict properties on the Chemicalize site


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