ChemSpider 2D Image | N-(2,4-Dimethylphenyl)-2,2,2-trifluoro-N'-[(E)-(3-methoxyphenyl)methylene]acetohydrazide | C18H17F3N2O2

N-(2,4-Dimethylphenyl)-2,2,2-trifluoro-N'-[(E)-(3-methoxyphenyl)methylene]acetohydrazide

  • Molecular FormulaC18H17F3N2O2
  • Average mass350.335 Da
  • Monoisotopic mass350.124207 Da
  • ChemSpider ID29341612
  • Double-bond stereo - Double-bond stereo


More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

Acetic acid, 2,2,2-trifluoro-, 1-(2,4-dimethylphenyl)-2-[(1E)-(3-methoxyphenyl)methylene]hydrazide [ACD/Index Name]
N-(2,4-Dimethylphenyl)-2,2,2-trifluor-N'-[(E)-(3-methoxyphenyl)methylen]acetohydrazid [German] [ACD/IUPAC Name]
N-(2,4-Dimethylphenyl)-2,2,2-trifluoro-N'-[(E)-(3-methoxyphenyl)methylene]acetohydrazide [ACD/IUPAC Name]
N-(2,4-Diméthylphényl)-2,2,2-trifluoro-N'-[(E)-(3-méthoxyphényl)méthylène]acétohydrazide [French] [ACD/IUPAC Name]
[1146963-51-0]
1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide, 2,2,2-trifluoro-acetic acid
1146963-51-0 [RN]
1807913-16-1 [RN]
2,2,2-Trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl) methylene]hydrazide
J 147
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CCRIS 4693 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Safety:

      Sold for research use only under license from the Salk Institute for Biological Studies Tocris Bioscience 5081
    • Bio Activity:

      Amyloid Beta Peptides Tocris Bioscience 5081
      Cell Biology Tocris Bioscience 5081
      Cell Metabolism Tocris Bioscience 5081
      J-147 is a broad spectrum neuroprotective phenyl hydrazide compound(EC50=60-115 nM) with significant neurotrophic properties related to the induction of brain-derived neurotrophic factor (BDNF).; IC50 value: 60-115 nM in vitro assay [1]; Target: ; J-147 has been shown to promotes HT22 and primary cell survival in a dose-dependent manner (EC50 value range of 0.06 ? 0.115 ?M) when applied to cell exposed to the mitochondrial neurotoxin, iodoacetic acid (IAA), toxicity mediated by the excitatory amino acid glutamate, which causes HT22 cell death by an oxytosis mechanism. MedChem Express HY-13779
      Neuroprotective and neurotrophic compound; reduces A?40 and A?42 levels Tocris Bioscience 5081
      Neuroprotective and neurotrophic compound; reduces Abeta40 and Abeta42 levels Tocris Bioscience 5081
      Others MedChem Express HY-13779
      Potent neuroprotective and neurotrophic compound. Protects against neurotoxicity in cortical neurons in vitro (EC50 = 25 - 200 nM). Reduces soluble A?40 and A?42 levels and increases BDNF levels in th e hippocampus in vivo. Enhances memory in wild type rats. Prevents memory deficits and rescues cognitive deficits in young and aged transgenic Alzheimer's disease mice, respectively. Orally active. Tocris Bioscience 5081
      Potent neuroprotective and neurotrophic compound. Protects against neurotoxicity in cortical neurons in vitro (EC50 = 25 - 200 nM). Reduces soluble A?40 and A?42 levels and increases BDNF levels in the hippocampus in vivo. Enhances memory in wild type rats. Prevents memory deficits and rescues cognitive deficits in young and aged transgenic Alzheimer's disease mice, respectively. Orally active. Tocris Bioscience 5081
      Potent neuroprotective and neurotrophic compound. Protects against neurotoxicity in cortical neurons in vitro (EC50 = 25 - 200 nM). Reduces soluble Abeta40 and Abeta42 levels and increases BDNF levels in the hippocampus in vivo. Enhances memory in wild type rats. Prevents memory deficits and rescues cognitive deficits in young and aged transgenic Alzheimer's disease mice, respectively. Orally active. Tocris Bioscience 5081

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.2±0.1 g/cm3
Boiling Point: 412.8±55.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.0 mmHg at 25°C
Enthalpy of Vaporization: 66.6±3.0 kJ/mol
Flash Point: 203.5±31.5 °C
Index of Refraction: 1.515
Molar Refractivity: 89.2±0.5 cm3
#H bond acceptors: 4
#H bond donors: 0
#Freely Rotating Bonds: 5
#Rule of 5 Violations: 1
ACD/LogP: 5.61
ACD/LogD (pH 5.5): 4.67
ACD/BCF (pH 5.5): 2075.26
ACD/KOC (pH 5.5): 8240.53
ACD/LogD (pH 7.4): 4.67
ACD/BCF (pH 7.4): 2075.30
ACD/KOC (pH 7.4): 8240.69
Polar Surface Area: 42 Å2
Polarizability: 35.4±0.5 10-24cm3
Surface Tension: 33.3±7.0 dyne/cm
Molar Volume: 296.0±7.0 cm3

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