ChemSpider 2D Image | LGD-4033 | C14H12F6N2O

LGD-4033

  • Molecular FormulaC14H12F6N2O
  • Average mass338.248 Da
  • Monoisotopic mass338.085388 Da
  • ChemSpider ID29364487
  • defined stereocentres - 2 of 2 defined stereocentres


More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1165910-22-4 [RN]
4-{(2R)-2-[(1R)-2,2,2-Trifluor-1-hydroxyethyl]-1-pyrrolidinyl}-2-(trifluormethyl)benzonitril [German] [ACD/IUPAC Name]
4-{(2R)-2-[(1R)-2,2,2-Trifluoro-1-hydroxyethyl]-1-pyrrolidinyl}-2-(trifluoromethyl)benzonitrile [ACD/IUPAC Name]
4-{(2R)-2-[(1R)-2,2,2-Trifluoro-1-hydroxyéthyl]-1-pyrrolidinyl}-2-(trifluorométhyl)benzonitrile [French] [ACD/IUPAC Name]
Benzonitrile, 4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]-1-pyrrolidinyl]-2-(trifluoromethyl)- [ACD/Index Name]
LGD-4033 [Wiki]
4-((R)-2-((R)-2,2,2-Trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-(trifluoromethyl)benzonitrile
4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]-1-pyrrolidinyl]-2-(trifluoromethyl)benzonitrile
4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]-1-pyrrolidinyl]-2-(trifluoromethyl)-benzonitrile
4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile
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  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Bio Activity:

      Androgen Receptor MedChem Express HY-13981
      LGD-4033 is a novel nonsteroidal, oral SARM that binds to androgen receptor with high affinity (Ki of 1 nM) and selectivity. MedChem Express
      LGD-4033 is a novel nonsteroidal, oral SARM that binds to androgen receptor with high affinity (Ki of 1 nM) and selectivity.;IC50 value: 1 nM (Ki, for androgen receptor) ;Target: androgen receptor;In vitro: LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, binds androgen receptor with high affinity and selectivity.;In vivo: LGD-4033 has demonstrated anabolic activity in the muscle, anti-resorptive and anabolic activity in bone, and robust selectivity for muscle versus prostate In animal models. LGD-4033 is well tolerated, has a long elimination half-life and dose-proportional accumulation upon multiple dosing. LGD-4033 is safe, has favorable pharmacokinetic profile, and increases lean body mass even during this short period without change in prostate-specific antigen. MedChem Express HY-13981

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.5±0.1 g/cm3
Boiling Point: 439.9±45.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.1 mmHg at 25°C
Enthalpy of Vaporization: 73.4±3.0 kJ/mol
Flash Point: 219.8±28.7 °C
Index of Refraction: 1.496
Molar Refractivity: 67.8±0.4 cm3
#H bond acceptors: 3
#H bond donors: 1
#Freely Rotating Bonds: 5
#Rule of 5 Violations: 0
ACD/LogP: 4.04
ACD/LogD (pH 5.5): 3.47
ACD/BCF (pH 5.5): 255.43
ACD/KOC (pH 5.5): 1839.63
ACD/LogD (pH 7.4): 3.47
ACD/BCF (pH 7.4): 255.42
ACD/KOC (pH 7.4): 1839.57
Polar Surface Area: 47 Å2
Polarizability: 26.9±0.5 10-24cm3
Surface Tension: 41.1±5.0 dyne/cm
Molar Volume: 231.9±5.0 cm3

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