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ChemSpider 2D Image | Dipyridamole | C24H40N8O4

Dipyridamole

  • Molecular FormulaC24H40N8O4
  • Average mass504.626 Da
  • Monoisotopic mass504.317261 Da
  • ChemSpider ID2997

More details:



Featured data source



Validated by Experts, Validated by Users, Non-Validated, Removed by Users

2,2',2",2"'-[(4,8-Di-1-piperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetrakisethanol
2,2',2'',2'''-[(4,8-Dipiperidin-1-ylpyrimido[5,4-d]pyrimidin-2,6-diyl)dinitrilo]tetraethanol
2,2',2'',2'''-[(4,8-dipipéridin-1-ylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tétraéthanol [French]
2,2',2'',2'''-{[4,8-Di(1-piperidinyl)pyrimido[5,4-d]pyrimidin-2,6-diyl]dinitrilo}tetraethanol [German] [ACD/IUPAC Name]
2,2',2'',2'''-{[4,8-Di(1-piperidinyl)pyrimido[5,4-d]pyrimidine-2,6-diyl]dinitrilo}tetraethanol [ACD/IUPAC Name]
2,2',2'',2'''-{[4,8-Di(1-pipéridinyl)pyrimido[5,4-d]pyrimidine-2,6-diyl]dinitrilo}tetraéthanol [French] [ACD/IUPAC Name]
2,2',2'',2'''-{[4,8-Di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine-2,6-diyl]dinitrilo}tetraethanol
58-32-2 [RN]
dipiridamol [Spanish] [INN]
dipyridamole [French] [INN]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

285676_ALDRICH [DBID]
D9766_SIGMA [DBID]
MFCD00010555 [DBID]
NSC619103 [DBID]
  • Experimental Physico-chemical Properties
  • Predicted Physico-chemical Properties
  • Miscellaneous
    • Safety:

      36/37/38 LKT Labs [D3362]
      GHS07 Biosynth W-105400
      H315 H319 H335 LKT Labs [D3362]
      H315; H319; H335 Biosynth W-105400
      IRRITANT Matrix Scientific 076583
      None LKT Labs [D3362]
      P261; P305+P351+P338 Biosynth W-105400
      Warning Biosynth W-105400
      Xi LKT Labs [D3362]
    • Target Organs:

      PDE inhibitor TargetMol T1618
    • Drug Status:

      approved BIONET-Key Organics HS-0041
    • Compound Source:

      synthetic Microsource [01500259]
    • Bio Activity:

      ADA;PDE TargetMol T1618
      Adenosine transport inhibitor Tocris Bioscience 0691, 691
      Coronary vasodilator; Zerenex Molecular [ZBioX-0164]
      Coronary vasodilator; adenosine transport inhibitor. Phosphodiesterase inhibitor (IC50 values are 0.37, 0.38, 0.45, 0.9 and 4.5 ?M for PDE11, 6, 10, 5 and 8 respectively). Inhibits ENT1 and ENT2 (IC5 0 = 144.8 nM and Ki = 8.18 nM for ENT1). Tocris Bioscience 0691
      Coronary vasodilator; adenosine transport inhibitor. Phosphodiesterase inhibitor (IC50 values are 0.37, 0.38, 0.45, 0.9 and 4.5 ?M for PDE11, 6, 10, 5 and 8 respectively). Inhibits ENT1 and ENT2 (IC50 = 144.8 nM and Ki = 8.18 nM for ENT1). Tocris Bioscience 691
      Coronary vasodilator; adenosine transport inhibitor. Phosphodiesterase inhibitor (IC50 values are 0.37, 0.38, 0.45, 0.9 and 4.5 muM for PDE11, 6, 10, 5 and 8 respectively). Inhibits ENT1 and ENT2 (IC50 = 144.8 nM and Ki = 8.18 nM for ENT1). Tocris Bioscience 691
      Dipyridamole (Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. MedChem Express
      Dipyridamole (Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.; Target: Phosphodiesterase (PDE); Dipyridamole concentrations of 1 nmol/ml blood caused 90% inhibition of adenosine metabolism. MedChem Express HY-B0312
      Dipyridamole (Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.;Target: Phosphodiesterase (PDE)Dipyridamole concentrations of 1 nmol/ml blood caused 90% inhibition of adenosine metabolism. Dipyridamole at therapeutic concentrations causes significant inhibition of adenosine metabolism in whole blood [1]. Dipyridamole has a dose-dependent inhibitory effect on thromboxane synthesis which was independent of aggregation. Dipyridamole also inhibited malonyldialdehyde production in response to both thrombin and arachidonic acid [2]. Dipyridamole enhances platelet inhibition by amplifying the signaling of the NO donor sodium nitroprusside. These data support the concept that enhancement of endothelium-dependent NO/cGMP-mediated signaling may be an important in vivo component of dipyridamole action [3]. MedChem Express HY-B0312
      Metabolic Enzyme/Protease; MedChem Express HY-B0312
      Metabolism TargetMol T1618
      Neurotransmitter Transporters Tocris Bioscience 691
      Nucleoside Transporters Tocris Bioscience 691
      Others MedChem Express HY-B0312
      PDE MedChem Express HY-B0312
      Transporters Tocris Bioscience 691
  • Gas Chromatography
    • Retention Index (Kovats):

      4550 (estimated with error: 89) NIST Spectra mainlib_237441, replib_247919
    • Retention Index (Normal Alkane):

      2648 (Program type: Ramp; Column cl... (show more) ass: Standard polar; Column length: 60 m; Column type: Capillary; CAS no: 58322; Active phase: DB-Wax; Carrier gas: N2; Phase thickness: 0.25 um; Data type: Normal alkane RI; Authors: Weyerstahl, P.; Marschall, H.; Thefeld, K.; Subba, G.C., Constituents of the essential oil from the rhizomes of Hedychium gardnerianum Roscoe, Flavour Fragr. J., 13, 1998, 377-388.) NIST Spectra nist ri
    • Retention Index (Linear):

      2095 (Program type: Ramp; Column cl... (show more) ass: Semi-standard non-polar; Column type: Capillary; CAS no: 58322; Active phase: DB-5; Data type: Linear RI; Authors: Konig, W.A.; Joulain, D.; Hochmuth, D.H., GC/MS Library: Terpenoids and Related Constituents of Essential Oils, 2006.) NIST Spectra nist ri

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.4±0.1 g/cm3
Boiling Point: 806.5±75.0 °C at 760 mmHg
Vapour Pressure: 0.0±3.0 mmHg at 25°C
Enthalpy of Vaporization: 122.9±3.0 kJ/mol
Flash Point: 441.5±37.1 °C
Index of Refraction: 1.670
Molar Refractivity: 139.4±0.3 cm3
#H bond acceptors: 12
#H bond donors: 4
#Freely Rotating Bonds: 12
#Rule of 5 Violations: 2
ACD/LogP: -1.22
ACD/LogD (pH 5.5): -0.42
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 6.43
ACD/LogD (pH 7.4): 0.30
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 33.96
Polar Surface Area: 145 Å2
Polarizability: 55.3±0.5 10-24cm3
Surface Tension: 81.6±3.0 dyne/cm
Molar Volume: 373.0±3.0 cm3

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