ChemSpider 2D Image | GDC-0623 | C16H14FIN4O3

GDC-0623

  • Molecular FormulaC16H14FIN4O3
  • Average mass456.210 Da
  • Monoisotopic mass456.009460 Da
  • ChemSpider ID30687718

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1168091-68-6 [RN]
5-[(2-Fluor-4-iodphenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridin-6-carboxamid [German] [ACD/IUPAC Name]
5-[(2-Fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide [ACD/IUPAC Name]
5-[(2-Fluoro-4-iodophényl)amino]-N-(2-hydroxyéthoxy)imidazo[1,5-a]pyridine-6-carboxamide [French] [ACD/IUPAC Name]
GDC-0623
HW67545I4Q
Imidazo[1,5-a]pyridine-6-carboxamide, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)- [ACD/Index Name]
5-((2-Fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide
5-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide
5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-imidazo[1,5-a]pyridine-6-carboxamide
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Chemical Class:

      A member of the class of imidazopyridines that is imidazo[1,5-a]pyridine substituted by (2-fluoro-4-iodophenyl)amino and (2-hydroxyethoxy)aminoacyl groups at positions 5 and 6. It is a potent ATP non- competitive inhibitor of MEK1 (Ki = 0.13nM) and also has efficacy against both mutant BRAF and mutant KRAS. It is in clinical development for treatment of patients with locally advanced or metastatic solid tumors. ChEBI CHEBI:167659

    • Bio Activity:

      GDC-0623 is a potent, ATP-uncompetitive inhibitors of MEK1(Ki=0.13 nM, +ATP); 6-fold weaker potency against HCT116 (KRAS(G13D), EC50=42 nM) versus A375 (BRAF(V600E), EC50=7 nM). MedChem Express
      GDC-0623 is a potent, ATP-uncompetitive inhibitors of MEK1(Ki=0.13 nM, +ATP); 6-fold weaker potency against HCT116 (KRAS(G13D), EC50=42 nM) versus A375 (BRAF(V600E), EC50=7 nM).; IC50 value: 0.13 nM (Ki, +ATP); 7 nM (EC50, A375 BRAF(V600E) ) [1]; Target: MEK1 MedChem Express HY-15610
      GDC-0623 is a potent, ATP-uncompetitive inhibitors of MEK1(Ki=0.13 nM, +ATP); 6-fold weaker potency against HCT116 (KRAS(G13D), EC50=42 nM) versus A375 (BRAF(V600E), EC50=7 nM).;IC50 value: 0.13 nM (Ki, +ATP); 7 nM (EC50, A375 BRAF(V600E) ) [1];Target: MEK1 MedChem Express HY-15610
      MAPK MedChem Express HY-15610
      MAPK; MedChem Express HY-15610
      MEK MedChem Express HY-15610

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.8±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.703
Molar Refractivity: 97.4±0.5 cm3
#H bond acceptors: 7
#H bond donors: 3
#Freely Rotating Bonds: 6
#Rule of 5 Violations: 0
ACD/LogP: 4.16
ACD/LogD (pH 5.5): 1.93
ACD/BCF (pH 5.5): 13.10
ACD/KOC (pH 5.5): 158.04
ACD/LogD (pH 7.4): 2.42
ACD/BCF (pH 7.4): 40.46
ACD/KOC (pH 7.4): 488.17
Polar Surface Area: 88 Å2
Polarizability: 38.6±0.5 10-24cm3
Surface Tension: 58.5±7.0 dyne/cm
Molar Volume: 251.1±7.0 cm3

Click to predict properties on the Chemicalize site


Advertisement