ChemSpider 2D Image | {(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(2S)-1-(isopropylsulfonyl)-3-methyl-2-butanyl]-3-methyl-2-oxo-3-piperidinyl}acetic acid | C28H35Cl2NO5S

{(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(2S)-1-(isopropylsulfonyl)-3-methyl-2-butanyl]-3-methyl-2-oxo-3-piperidinyl}acetic acid

  • Molecular FormulaC28H35Cl2NO5S
  • Average mass568.552 Da
  • Monoisotopic mass567.161316 Da
  • ChemSpider ID31132728
  • defined stereocentres - 4 of 4 defined stereocentres


More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

{(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(2S)-1-(isopropylsulfonyl)-3-methyl-2-butanyl]-3-methyl-2-oxo-3-piperidinyl}acetic acid [ACD/IUPAC Name]
{(3R,5R,6S)-5-(3-Chlorphenyl)-6-(4-chlorphenyl)-1-[(2S)-1-(isopropylsulfonyl)-3-methyl-2-butanyl]-3-methyl-2-oxo-3-piperidinyl}essigsäure [German] [ACD/IUPAC Name]
1352066-68-2 [RN]
3-Piperidineacetic acid, 5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(1S)-2-methyl-1-[[(1-methylethyl)sulfonyl]methyl]propyl]-2-oxo-, (3R,5R,6S)- [ACD/Index Name]
Acide {(3R,5R,6S)-5-(3-chlorophényl)-6-(4-chlorophényl)-1-[(2S)-1-(isopropylsulfonyl)-3-méthyl-2-butanyl]-3-méthyl-2-oxo-3-pipéridinyl}acétique [French] [ACD/IUPAC Name]
[1352066-68-2]
10.1021/jm401753e
2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid
AMG 232
AMG232
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

7R7G6EH5UL [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Bio Activity:

      AMG 232 is a highly potent, selective and orally bioavailable piperidinone inhibitor of the MDM2-p53 interaction((SPR KD= 0.045 nM, SJSA-1 EdU IC50=9.1 nM). MedChem Express
      AMG 232 is a highly potent, selective and orally bioavailable piperidinone inhibitor of the MDM2-p53 interaction((SPR KD= 0.045 nM, SJSA-1 EdU IC50=9.1 nM).; IC50 value: 9.1 nM (EdU proliferation assay) [1]; Target: MDM2/p53; AMG 232 was an extremely potent MDM2 inhibitor in all assays, especially in the EdU proliferation assay (IC50= 9.1 nM). MedChem Express HY-12296
      Apoptosis MedChem Express HY-12296
      Apoptosis; MedChem Express HY-12296
      MDM-2, p53 MedChem Express HY-12296

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.3±0.1 g/cm3
Boiling Point: 732.7±60.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.5 mmHg at 25°C
Enthalpy of Vaporization: 112.2±3.0 kJ/mol
Flash Point: 396.9±32.9 °C
Index of Refraction: 1.564
Molar Refractivity: 147.5±0.4 cm3
#H bond acceptors: 6
#H bond donors: 1
#Freely Rotating Bonds: 9
#Rule of 5 Violations: 2
ACD/LogP: 6.05
ACD/LogD (pH 5.5): 4.25
ACD/BCF (pH 5.5): 508.39
ACD/KOC (pH 5.5): 1340.88
ACD/LogD (pH 7.4): 2.47
ACD/BCF (pH 7.4): 8.32
ACD/KOC (pH 7.4): 21.96
Polar Surface Area: 100 Å2
Polarizability: 58.5±0.5 10-24cm3
Surface Tension: 46.3±3.0 dyne/cm
Molar Volume: 453.3±3.0 cm3

Click to predict properties on the Chemicalize site





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