ChemSpider 2D Image | G749 | C25H25BrN6O2

G749

  • Molecular FormulaC25H25BrN6O2
  • Average mass521.409 Da
  • Monoisotopic mass520.122253 Da
  • ChemSpider ID32813334

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1457983-28-6 [RN]
8-Brom-2-[(1-methyl-4-piperidinyl)amino]-4-[(4-phenoxyphenyl)amino]pyrido[4,3-d]pyrimidin-5(6H)-on [German] [ACD/IUPAC Name]
8-Bromo-2-[(1-methyl-4-piperidinyl)amino]-4-[(4-phenoxyphenyl)amino]pyrido[4,3-d]pyrimidin-5(6H)-one [ACD/IUPAC Name]
8-Bromo-2-[(1-méthyl-4-pipéridinyl)amino]-4-[(4-phénoxyphényl)amino]pyrido[4,3-d]pyrimidin-5(6H)-one [French] [ACD/IUPAC Name]
B06W426B66
G749
G-749
Pyrido[4,3-d]pyrimidin-5(6H)-one, 8-bromo-2-[(1-methyl-4-piperidinyl)amino]-4-[(4-phenoxyphenyl)amino]- [ACD/Index Name]
[1457983-28-6] [RN]
8-?bromo-?2-?[(1-?methyl-?4-?piperidinyl)?amino]?-?4-?[(4-?phenoxyphenyl)?amino]?-Pyrido[4,?3-?d]?pyrimidin-?5(6H)?-?one
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

NSC5844 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      FLT3 inhibitor TargetMol T2620

    • Bio Activity:

      Angiogenesis TargetMol T2620
      FLT3 MedChem Express HY-12333
      FLT3;Mer;Aurora B;RET;VEGFR1/FLT1; Fms; Axl;Aurora C;FGFR1;FGFR3; VEGFR2/KDR; c-kit TargetMol T2620
      G-749 is a novel FLT3 inhibitor that showed potent and sustained inhibition of the FLT3 wild type and mutants with IC50s of 0.4/0.6/3.5/7.5 nM for Wt Flt3/D835Y/MV4-11/Molm-14 respectively. MedChem Express
      G-749 is a novel FLT3 inhibitor that showed potent and sustained inhibition of the FLT3 wild type and mutants with IC50s of 0.4/0.6/3.5/7.5 nM for Wt Flt3/D835Y/MV4-11/Molm-14 respectively.; IC50 value: 0.4/0.6/3.5/7.5 nM(Wt Flt3/D835Y/MV4-11/Molm-14) [1]; Target: Flt3 inhibitor; G-749 showed potent and sustained inhibition of the FLT3 wild type and mutants including FLT3-ITD, FLT3-D835Y, FLT3-ITD/N676D, and FLT3-ITD/F691L in cellular assays. MedChem Express HY-12333
      G-749 is a novel FLT3 inhibitor that showed potent and sustained inhibition of the FLT3 wild type and mutants with IC50s of 0.4/0.6/3.5/7.5 nM for Wt Flt3/D835Y/MV4-11/Molm-14 respectively.;IC50 value: 0.4/0.6/3.5/7.5 nM(Wt Flt3/D835Y/MV4-11/Molm-14) [1];Target: Flt3 inhibitorG-749 showed potent and sustained inhibition of the FLT3 wild type and mutants including FLT3-ITD, FLT3-D835Y, FLT3-ITD/N676D, and FLT3-ITD/F691L in cellular assays. G-749 retained its inhibitory potency in various drug-resistance milieus such as patient plasma, FLT3 ligand surge, and stromal protection. Furthermore, it displayed potent antileukemic activity in bone marrow blasts from AML patients regardless of FLT3 mutation status, including those with little or only minor responses to AC220 or PKC412. Oral administration of G-749 yielded complete tumor regression and increased life span in animal models. MedChem Express HY-12333
      Protein Tyrosine Kinase/RTK MedChem Express HY-12333
      Protein Tyrosine Kinase/RTK; MedChem Express HY-12333

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.5±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.701
Molar Refractivity: 135.6±0.3 cm3
#H bond acceptors: 8
#H bond donors: 3
#Freely Rotating Bonds: 6
#Rule of 5 Violations: 1
ACD/LogP: 2.86
ACD/LogD (pH 5.5): 0.95
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 3.88
ACD/LogD (pH 7.4): 2.44
ACD/BCF (pH 7.4): 19.89
ACD/KOC (pH 7.4): 121.26
Polar Surface Area: 91 Å2
Polarizability: 53.8±0.5 10-24cm3
Surface Tension: 68.4±3.0 dyne/cm
Molar Volume: 350.5±3.0 cm3

Click to predict properties on the Chemicalize site


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