ChemSpider 2D Image | altiratinib | C26H21F3N4O4

altiratinib

  • Molecular FormulaC26H21F3N4O4
  • Average mass510.465 Da
  • Monoisotopic mass510.151489 Da
  • ChemSpider ID33427355

More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1,1-Cyclopropanedicarboxamide, N-[4-[[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]oxy]-2,5-difluorophenyl]-N'-(4-fluorophenyl)- [ACD/Index Name]
10100
1345847-93-9 [RN]
altiratinib [INN] [USAN]
altiratinib [French] [INN]
altiratinib [Spanish] [INN]
altiratinibum [Latin] [INN]
DCC-2701
DP-5164
N-[4-({2-[(Cyclopropylcarbonyl)amino]-4-pyridinyl}oxy)-2,5-difluorophenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide [ACD/IUPAC Name]
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Target Organs:

      c-Met inhibitor; Tie-2 inhibitor; VEGFR inhibitor TargetMol T2054
    • Bio Activity:

      Altiratinib(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with a HGF an tagonist in vitro. MedChem Express http://www.medchemexpress.com/CZC-54252.html
      Altiratinib(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with a HGF antagonist in vitro. MedChem Express HY-B0791
      c-Met/HGFR MedChem Express HY-B0791
      c-Met/HGFR VEGFR MedChem Express HY-B0791
      c-MET/TIE-2/VEGFR TargetMol T2054
      Protein Tyrosine Kinase/RTK MedChem Express HY-B0791
      Protein Tyrosine Kinase/RTK; MedChem Express HY-B0791
      Tyrosine Kinase/Adaptors TargetMol T2054

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.6±0.1 g/cm3
Boiling Point: 763.5±60.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.6 mmHg at 25°C
Enthalpy of Vaporization: 111.2±3.0 kJ/mol
Flash Point: 415.6±32.9 °C
Index of Refraction: 1.703
Molar Refractivity: 127.1±0.3 cm3
#H bond acceptors: 8
#H bond donors: 3
#Freely Rotating Bonds: 8
#Rule of 5 Violations: 1
ACD/LogP: 4.20
ACD/LogD (pH 5.5): 3.51
ACD/BCF (pH 5.5): 273.50
ACD/KOC (pH 5.5): 1920.37
ACD/LogD (pH 7.4): 3.52
ACD/BCF (pH 7.4): 279.24
ACD/KOC (pH 7.4): 1960.67
Polar Surface Area: 109 Å2
Polarizability: 50.4±0.5 10-24cm3
Surface Tension: 80.6±3.0 dyne/cm
Molar Volume: 327.7±3.0 cm3

Click to predict properties on the Chemicalize site






Advertisement